Then, you must continuously monitor the performance of thesynthetic control armthroughout the trial to ensure it remains valid and reliable. And at the end, you can analyse the outcomes using the combined data from both the SCA and the active treatment arm. What are the benefits of using SCAs?
We propose a novel nonparametric Bayesian common atoms mixture model that allows us to find equivalent population strata in the EHR and the treatment arm and then resample the EHR data to create equivalent patient populations under both the single arm trial and the resampled EHR. Resampling is ...
In a poster presentation titledPhase IB trial efficacy estimates via a clinical trial synthetic control arm, Dr. Elizabeth Lamont presented the research team’s findings that demonstrated how comparing patients from a single-arm trial can help enhance understanding of tre...
As advanced non-small cell lung cancer (aNSCLC) is being increasingly divided into rare oncogene-driven subsets, conducting randomised trials becomes challenging. Using real-world data (RWD) to construct control arms for single-arm trials provides an opt
In a poster presentation entitled “Phase IB trial efficacy estimates via a clinical trial synthetic control arm”, on Monday April 11, 2022 from 9 AM through 12:00 PM EST, Dr. Elizabeth Lamont presented the research team...
In a small number of case reports, substantial increases in blood pressure have been attributed to idiosyncratic reactions to estrogens. In a large, randomized, placebo controlled clinical trial, a generalized effect of estrogens on blood pressure was not seen. ...
et al. Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial. Nat Metab 5, 1685–1690 (2023). https://doi.org/10.1038/s42255-023-00897-6 Download citation Received10 February 2023 Accepted25 August 2023 Published28 September 2023 Issue Date...
A learning-based method for online adjustment of C-arm cone-beam CT source trajectories for artifact avoidance. Int. J. Comput. Assist. Radiol. Surg. 15, 1787–1796 (2020). Article Google Scholar Park, J., Han, D. K. & Ko, H. Adaptive weighted multi-discriminator cyclegan for under...
(A) 1 μm polystyrene templates, (B) mixed collagen-PPS hollow spheres, (C) mixed collagen-dithiolPEG hollow spheres (control), (D) mixed collagen-4armPEG hollow spheres (control). Full size image Figure 2 Hollow spheres TEM imaging and DLS analysis. (A) 1 μm polystyrene templates, (...
Control arms - Using synthetic data to generate control arms can benefit both operators and patients, says Craig Lipset, Advisor and Founder at Clinical Innovation Partners. “The ability to decrease the size of the control arm by supplementing it with synthetic data or replacing the need for it...