Synaptic vesicle protein 2 (SV2) is a glycoprotein identified in the nervous system of several species, including man, but its occurrence in the human neuroendocrine (NE) cell system has not been investigated. By using a monoclonal antibody to SV2, immunoreactivities were demonstrated in NE ...
Synaptic vesicleglycoprotein 2 (SV2) occurs in two main isoforms in the brain, SV2A and SV2B. This protein can bind twoadeninemolecules and possibly links cellular energy state to vesicle release. Mice engineered to lack both SV2 isoforms possess a smaller number of readily releasable SVs, whi...
Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein specifically localized to secretory vesicles in neurons and endocrine cells. As a first step toward understanding the function of SV2 in neural secretion, a rat brain complementary DNA (cDNA) that encodes SV2 was isolated and characterize...
et al. Assessing synaptic density in Alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging. JAMA Neurol. 75, 1215–1224 (2018). Article Google Scholar Mecca, A. P. et al. Association of entorhinal cortical tau deposition and hippocampal synaptic density in ...
It was only when we combined pH 10, DM, and RNAse that we observed degradation of the ~32 nt band (Fig.1c). We have previously used a single-vesicle imaging approach to study the co-localization of multi- ple types of vesicular transporters to single vesicles in the cholinergic SV ...
We have hypothesized that proteins mediating cell-c... CP Blobel,TG Wolfsberg,CW Turck,... - 《Nature》 被引量: 1404发表: 1992年 Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells. Several types of cells store proteins in secretory ...
238 003 M6a Glycoprotein 50 µg 6500 Synaptic Systems 238 005 M6a Glycoprotein 50 µg 7300 Synaptic Systems 238-0P M6a Glycoprotein 100 µg 1400 Synaptic Systems 239 003 CLIP 170 50 µg 6500 Synaptic Systems 239 005 CLIP 170 50 µg 7300 Synaptic Systems 240 003 beta1-Integrin 50...
We attempted to meld these observations into a unified model for axonal transport in mammalian neurons by testing two alternative hypotheses: (1) that SV and lysosomal proteins are co-transported within a single type of “lysosome-related vesicle” and (2) that SVPs and lysosomes are distinct ...
Fig. 2. Top: Specific binding (cp/s/mm2) of [3H]UCB-J to synaptic vesicle glycoprotein 2A (SV2A) in the prefrontal cortex (PFC), nucleus accumbens (NA), caudate (CAU), putamen (PUT), hippocampus (HIP), and thalamus (THAL) of sucrose-consuming animals and controls. Bottom: Representa...
Among validated CELF4-targets is the mRNA encoding the synaptic vesicle glycoprotein 2 A (SV2A). SV2A is highly expressed in all glutamatergic and GABAergic cortical subtypes, both of which are also present in the developing SP4,5,6,7,9,10,11,12,13,14,17. Recent studies have identifie...