Synaptic Vesicle Glycoprotein 2C (SV2C), characterized by its selective expression in discrete brain regions such as the midbrain, has recently emerged as a promising player in Parkinson's Disease (PD) - a debilitating neurodegenerative disorder affecting millions worldwi...
B. et al. Synthesis and preclinical evaluation of 11C-UCB-J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain. J. Nucl. Med. 57, 777–784 (2016). CAS PubMed Google Scholar Dong, M. et al. SV2 is the protein receptor for botulinum neurotoxin A. ...
The synaptic vesicle glycoprotein SV2A belongs to the major facilitator superfamily (MFS) of transporters and is an integral constituent of synaptic vesicle membranes. SV2A has been demonstrated to be involved in vesicle trafficking and exocytosis, processes crucial for neurotransmission. The anti-seizure...
The synaptic vesicle glycoprotein SV2A belongs to the major facilitator superfamily (MFS) of transporters and is an integral constituent of synaptic vesicle membranes. SV2A has been demonstrated to be involved in vesicle trafficking and exocytosis, processes crucial for neurotransmission. The anti-seizure...
Synaptic vesicle protein 2 (SV2) is a glycoprotein identified in the nervous system of several species, including man, but its occurrence in the human neuroendocrine (NE) cell system has not been investigated. By using a monoclonal antibody to SV2, immunoreactivities were demonstrated in NE ...
Synaptic vesicle glycoprotein 2 (SV2) occurs in two main isoforms in the brain, SV2A and SV2B. This protein can bind two adenine molecules and possibly links cellular energy state to vesicle release. Mice engineered to lack both SV2 isoforms possess a smaller number of readily releasable SVs...
(dedicator of cytokinesis 10), Sv2b (synaptic vesicle glycoprotein 2B), Marcks (myristoylated alanine rich protein kinase C substrate), Cap2 (cyclase-associated actin cytoskeleton regulatory protein 2), Kcnc1 (potassium voltage-gated channel subfamily C member 1), Ctnnd2 (catenin delta 2), Pak3...
Synaptic vesicle glycoprotein 2A (SV2A) has been previously characterized as an imaging biomarker for assessment of synaptic density in positron emission tomography (PET) studies of patients with neurological conditions. To provide detailed maps of the brain localization of SV2A autoradiography studies we...
The radioligand [11C]UCB-J quantifies synaptic density through selective binding to the presynaptic vesicle glycoprotein 2 A (SV2A). When used in positron emission tomography (PET) imaging, it confirms the reduction of synaptic density in bvFTD10, CBS and PSP9,15. Reductions in [11C]UCB-...
The radioligand [11C]UCB-J quantifies synaptic density through selective binding to the presynaptic vesicle glycoprotein 2 A (SV2A). When used in positron emission tomography (PET) imaging, it confirms the reduction of synaptic density in bvFTD10, CBS and PSP9,15. Reductions in [11C]UCB-...