Patients are ranked according to their progression rates and those who expressed the highest rates of MDS-UPDRS total score increase per year of follow-up period are assigned into the rapid progression class, using 5- and 10-quantiles partition. Classification performance against the rapid ...
Diamond SG, Markham CH, Hoehn MM, McDowell FH, Muenter MD (1989) Effect of age at onset on progression and mortality in Parkinson’s disease. Neurology 39:1187–1190 Article CAS PubMed Google Scholar Kagi G, Klein C, Wood NW et al (2010) Nonmotor symptoms in Parkin gene-related park...
In this regard, a comparison with SCA, another subgroup of hereditary ataxias with a different cerebellar and extra-cerebellar degeneration pattern, is particularly interesting. Most studies on NPS in SCA do not find a linear relationship between measures of disease progression and NPS49,50,51,52...
Oxidative stresscan lead to inflammation, while inflammation can also cause oxidative stress. Through a self-perpetuating process, these two contribute to the progression of MS [79]. Learn More Multiple Sclerosis: Dietsand Complementary Approaches Multiple Sclerosis: Genes, Epidemiology & Prevention Find...
Motor symptoms of PD were assessed with part III of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS III). Cognition, daytime sleepiness, depression, constipation, and REM sleep behavior disorder were evaluated respectively by the Montreal Cognitive assessment (MoCa, cutoff for cognitive ...
32 Furthermore, the between-group difference for the MDS-UPDRS motor subscores was comparable to the reported within-person minimal clinically important improvement of 3.2.33 In light of a recent report that low-dose, patient-centered, goal-directed physiotherapy and occupational therapy in patients...
The neurodegeneration in Parkinson's disease leads to a triad of motor symptoms including bradykinesia, muscle rigidity and resting tremor. Likewise, a variety of non-motor symptoms are related to the progression of the disease, including sleep disorders, gastrointestinal and autonomic symptoms (nausea...
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Head of the Leukemia and MDS Section Moffitt Cancer Center Tampa, FL Targeted OncologyTM: What do the National Comprehensive Cancer Network (NCCN) guidelines recommend for patients with higher-risk myelofibrosis? RAMI KOMROKJI, MD: [Based on the guidelines, for] higher risk, we consider [stem ...
Methods We analyzed the baseline clinical data of 412 PD patients, 184 controls, and 62 SWEDDs included in the Parkinson's Progression Marker Initiative study on a variety of different NMS questionnaires. Results Both PD patients and SWEDDs had greater frequency of NMS than healthy controls. ...