Bexmarilimab (FP-1305) in combination with standard-of-care (SOC) azacitidine or azacitidine plus venetoclax (Venclexta) demonstrated early signs of efficacy in patients with relapsed or refractory acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), according to updated data fr...
a gene expression was observed for the all 6 genes, did not fully separate eels from the Mauguio and Salses-Leucate lagoons, individuals from the two localities tended to appear in distinct parts of the ordination plot, with those from Mauguio being mostly located in the upper part of MDS2...
doi: 10.1002/mds.26134Antoniades CA, Demeyere N, Kennard C, Humphreys GW, Hu MT. Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: the discovery study. Mov Disord 2015; 30: 843-847.Antoniades CA, Demeyere N, Kennard C, Humphreys GW, Hu MT (2015) Antisaccade...
We report on an Italian family in which three brothers and their maternal grandfather had a generalized early-onset dystonia with mild parkinsonian signs. ... G Fabbrini,F Brancati,L Vacca,... - 《Movement Disorders》 被引量: 0发表: 2005年 Phenotypic expression of the DYT1 mutation: a fami...
2 study, the primary endpoint (Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) sum of Parts I + II + III) was not met, prasinezumab-treated individuals exhibited slower progression of motor signs than placebo-treated participants (MDS-UPDRS Part III)....
of prasinezumab on slowing motor signs progression (MDS-UPDRS Part III) was greater in the rapidly progressing subpopulations (for example, participants who were diffuse malignant or taking monoamine oxidase B inhibitors at baseline). This exploratory analysis suggests that, in a trial of 1-year ...
Some signs of such accumulation in rat soleus muscle after HS were observed by Wakatsuki et al. [17] using NMR spectroscopy. It should also be expected that a direct consequence of ATP accumulation and a corresponding decrease in AMP can be a decrease in the phosphorylation...
In SOLO-2, patients withBRCAm platinum-sensitive relapsed ovarian cancer, the incidence of MDS/AML was 8% (15/195) in patients who received LYNPARZA and 4% (4/99) in patients who received placebo. The duration of LYNPARZA treatment prior to the diagnosis of MDS/AML ranged from 0.6 yea...
Fig. 3: Correlations of perivascular space burden indexes in BG and midbrain with clinical features. Correlations with a−d MDS-UPDRS scores and e LEDD in PD. Correlations with f−h HAMD score in PD and HC. Correlation with i−j PANDA score in PD and HC. *Indicates the partial...
Evidence from both human and animal models has demonstrated that before clear signs of neurodegeneration appear in specific brain regions, other dysfunctions occur in the same neuronal circuits at a synaptic level in apparently intact cells. Indeed, being α-syn a presynaptic protein, any toxic effec...