These changes are comparable to the abnormalities observed in myelodysplastic syndromes (MDS). Another link between mitochondrial dysfunction and disordered hematopoiesis is provided by Pearson's syndrome, a rare congenital disorder presenting in infancy with a variety of symptoms, including refractory ...
Despite the abundance of research investigating the associations between maternal depressive symptoms (MDS) and children's cognitive development, little is known about the putative mechanisms through which depressive symptoms are associated with children's cognitive development. The aim of this review was ...
EP: 3.Symptoms and Manifestations of Chronic GVHD Now Viewing EP: 4.Early Diagnosis of Chronic GVHD and Tools for Severity Assessment EP: 5.Treatment Options for Steroid-Refractory Chronic GVHD EP: 6.Ruxolitinib Efficacy in Steroid-Refractory Chronic GVHD ...
As to the first point, GvHD will start in most patients with mild symptoms involving either skin, liver, gut, or combinations.11 Some will improve on low-dose of prednisolone, some will remain stable, and a fraction will deteriorate and develop severe GvHD.11, 12, 13 The question is, if...
Among them, Hutchinson–Gilford Progeria Syndrome (HGPS, OMIM 176670) is caused by a de novo point mutation in the LMNA gene27, resulting in a truncated splicing mutant form of Lamin A protein, known as progerin. The disease phenotype is characterized by the early onset of several symptoms,...
In these subpopulations, the effect of prasinezumab on slowing motor signs progression (MDS-UPDRS Part III) was greater in the rapidly progressing subpopulations (for example, participants who were diffuse malignant or taking monoamine oxidase B inhibitors at baseline). This exploratory analysis ...
The swallowing disturbance questionnaire (SDQ [18]) focuses on the detection of aspiration episodes, but is not designed to detect symptoms of early dysphagia. Moreover, its limited clinimetric properties have been criticized [19]. MDS-UPDRS Part II [20] and NMSQuest [21] only include two ...
In the cross‐sectional analysis, baseline striatal DAT binding was significantly associated with the Hoehn and Yahr scale, the Movement Disorder Society‐Sponsored Revision of the Unified Parkinson Disease Rating Scale (MDS‐UPDRS) scores, the rigidity scores, and the axial scores in P...
While these next-generation ARPIs can effectively reduce symptoms and prolong life, metastatic CRPC (mCRPC) remains incurable as resistance to these ARPIs frequently emerges. Furthermore, although multiple ARPIs are currently in clinical use, most of these therapies focus on late stages of the ...
A 43 year old male presented with a marked eosinophilia and associated systemic symptoms. A diagnosis of myelodysplasia was made on the basis of bone marro... GA Follows,RG Owen,AJ Ashcroft,... - 《Journal of Clinical Pathology》 被引量: 19发表: 1999年 A comparison of the incidence of ...