This review describes the structure of telomeres, the protective DNA-protein complexes at eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere functions. Also discussed are cellular responses to compromising the functions of telomeres and of telomerase, which synthesizes telomeri...
et al. Radiation-induced cell signaling: inside-out and outside-in. Mol. Cancer Ther. 6, 789–801 (2007). Article CAS PubMed Google Scholar Sahin, E. et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470, 359–365 (2011). Article CAS PubMed PubMed ...
many studies indicate that the p53 signal transduction pathway is intrinsically intact in neuroblastoma,1,4,7–9 sug- gesting that circumvention of the p53 barrier in this tumor entity relies primarily on an inappropriately increased activity of inhibitors of p53 signaling or, alternatively, on a ...
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a high migration and proliferation capacity ...
Signaling aptamers created using fluorescent nucleotide analogues. Anal. Chem. 2006, 78, 6484–6489. 28. Wilhelmsson, L.M.; Sandim, P.; Holmen, A.; Albinsson, B.; Lincoln, P.; Nielsen, P.E.; Norden, B. Photophysical characterization of fluorescent DNA base analogue, tC. J. Phys. ...