Telomerase is responsible for the replication of telomere DNA. It synthesizes telomere repeats through its catalytic telomerase reverse transcriptase subunit (TERT). Evidence suggested that BDNF and telomere length are also associated with neural survival and cognitive function [64]. In rodent models, ...
For example, individuals with dyskeratosis congenita, a disease caused by germline loss-of-function mutations in the telomerase component genes TERC and TERT have chronically short telomeres and are at increased risk of some cancers, particularly acute myeloid leukemia and squamous cell carcinomas ...
Telomerase, a multi-subunit ribonucleoprotein complex, is a unique reverse transcriptase that catalyzes the processive addition of a repeat sequence to extend the telomere end using a short fragment of its own RNA component as the template. Despite recen
Telomeres shorten with each cell division [4] and once a critical telomere length is reached, a DNA damage response is triggered, resulting in cellular senescence or apoptosis [5, 6]. To circumvent the limited number of possible cell divisions, tumors employ activation of telomerase [7] or ...
Telomerase is transcriptionally upregulated by NF-κb, a key regulator of inflammation, and telomerase can directly regulate NF-κb-dependent gene expression in human cancers (Ghosh et al. 2012). Previous studies have shown that atmospheric pollution is associated with increased circulating band cell ...
leading to progressive TL shortening throughout the life course. In other organisms, telomerase expression is maintained throughout life5,6,7, and TL does not decrease with age8. In many invertebrates and aquatic vertebrates, the persistent activity of telomerase in somatic tissues may be associated...
Previous observational studies have highlighted potential relationships between the telomerase reverse transcriptase (TERT) gene, short leukocyte telomere length (LTL), and cerebrovascular disease. However, it remains to be established as to whether TERT gene variants are associated with an elevated risk ...
In contrast, normal human cells have naturally limited levels of telomerase that can lead to telomere shortening over time. Many aspects of telomeres remain incompletely understood, especially their dynamic properties and behavior over time. At one extreme, over the decades of human lifespan, ...
An update on phytochemicals in molecular target therapy of cancer: potential inhibitory effect on telomerase activity. Curr Med Chem. 2016;23:2380–93.10.2174/0929867323666160425113705Search in Google Scholar PubMed [20] Davinelli S, Scapagnini G. Lifespan and healthspan extension by nutraceuticals:...
homology directed recombination and the activation of key features of the ALT pathway. This indicates a critical role for 2,2,7-TMG capping of the RNA component of human telomerase (hTR) in enforcing telomerase-dependent telomere maintenance to restrict the formation of telomeric substrates conductive...