origin of DNA replicationSV40simian virus 40In earlier studies we had shown that a transcriptional enhancer sequence exists about 2 kb upstream of the human c- myc gene. The core sequence necessary for enhancer activity was defined therein as a 21 bp nucleotide element, which also showed ...
Simian virus 40 (SV40) enhancer and early promoter, with the SV40 origin of replication. Try SnapGene for Free |Download SnapGene Viewer Explore Over2.7kPlasmids:Basic Cloning Vectors|More Plasmid Sets Show Static Map SexAI*CsiIStart(0)CsiICsiISexAI*SexAI*Start(0)Start(0)5ʹ3ʹ80PSV40 ...
Origin of SV40 DNA ReplicationNo Abstract available for this article.doi:10.1038/236329b0NoneNature Publishing Group UKNature
The simian virus 40 (SV40) large T antigen (large tumor antigen), in conjunction with a topoisomerase, a DNA binding protein, and ATP, catalyzed the conversion of a circular duplex DNA molecule containing the SV40 origin of replication to a form with unusual electrophoretic mobility that we hav...
The J domain is responsible for binding to the viral origin of replication. It contains two zinc finger motifs that interact with specific sequences within the origin. The HhH domain is responsible for binding to the ATPase domain of the CD. It contains a helix-hairpin-helix motif that intera...
To define the sequence elements involved in initiation of DNA synthesis at the simian virus 40 origin of replication, we determined the relative replicatio... JJ Li,KW Peden,RA Dixon,... - 《Mol.cell.biol》 被引量: 144发表: 1986年 Purification and functional characterization of bovine RP-...
Indeed, amplified sequences were collinear with the integrated p205-GTI copy and its surrounding cellular sequences, distributed almost equally around the SV40 replication origin, and circularized by illegitimate recombination which did not involve specific nucleotide sequences. This system is of interest...
The strongest cleavage site maps near the origin of SV40 DNA replication at nucleotide 31-32 and has a pentanucleotide sequence of 5'-TGACT-3'... KA Edwards,BD Halligan,JL Davis,... - 《Nucleic Acids Research》 被引量: 166发表: 1982年 The nucleotide sequence preceding an RNA polymerase...
A low frequency of Et743 adducts detected at 30−100 nM drug concentrations inhibited SV40 origin activity and induced formation of unusual DNA replication intermediates. Under cell-free conditions, only a high Et743 adduct frequency reduced SV40 DNA synthesis. Comparative studies involving related ...
Simian virus 40 (SV40), a polyomavirus of rhesus macaque origin, was discovered in 1960 as a contaminant of polio vaccines that were distributed to million... JS Butel,JA Lednicky - 《Journal of the National Cancer Institute》 被引量: 836发表: 1999年 Simian virus 40 in human cancers Many...