SURVIVAL PREDICTOR FOR DIFFUSE LARGE B CELL LYMPHOMAThe invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.STAUDT, Louis, M.
BACKGROUND: Several gene-expression signatures can be used to predict the prognosis in diffuse large-B-cell lymphoma, but the lack of practical tests for a genome-scale analysis has restricted the use of this method. METHODS: We studied 36 genes whose expression had been reported to predict s...
Numbers of cases and sex-rate ratios by sub-type and age: Haematological Malignancy Research Network (HMRN) 2004–2012. Full size image In general, males tend to be diagnosed with B-cell lymphomas at younger ages than females (Table 1) and, with one or two exceptions, experience higher r...
An introduction is provided which discusses an article in the issue on the role that immunotherapy has played in the survival of B-cell non-Hodgkin lymphoma patients in Queensland from 1993 through 2012.doi:10.5694/mja18.00626Olver Ian N
Patients with refractory large B-cell lymphoma who were treated with Axi-cel had a 3-year overall survival rate of 47%, according to an updated analysis of the phase II ZUMA-1 trial.
(1972). In the range ofB≤ 0.50 K min-1, the survival rate decreased because the value ofΔVcellmax¯increased along with the decrease of B. In contrast, in the range ofB≥ 3.0 K min-1, the value ofVicemax¯increased with the increase ofB, which decreased thecell survival rate. ...
The intrinsic apoptotic pathway is defined by mitochondrial outer membrane permeabilization (MOMP). Intrinsic stressors upregulate the expression/activation of proapoptotic B cell lymphoma 2 (BCL-2) proteins and suppress anti-apoptotic BCL-2 family proteins, resulting in MOMP [151]. This outcome sug...
Introduction: Multiple conflicting prognostic markers have been proposed for R‐CHOP treated diffuse large B‐cell lymphoma (DLBCL) cases. Aggressive behaviour has been shown to be associated with ABC‐like phenotype, Double Hit (DH) or Double Expression (DE) phenotype, CD5 expression and other ...
4, 5, 7, 8, 9, 10 This concept is supported by the observation of discrepancies in bcl-2 protein expression between follicular B-cell non-Hodgkin’s lymphoma (NHL) cells, which exhibit high levels of bcl-2, and their normal counterparts, proliferating germinal center cells, which appear ...
2F). Similarly, we verified the predictive ability of this immune-related lncRNA signature in the entire TCGA cohort and found that the AUC for 1-, 3-, and 5-year OS were 0.710, 0.716, and 0.799, respectively (Fig. 2G). Vital status analysis showed that the patient mortality rate ...