SUMO-specificproteaseSUSP4positivelyregulates p53bypromotingMdm2self-ubiquitination MoonHeeLee 1 ,SungWonLee 1 ,EunJooLee 1 ,SooJoonChoi 1 ,SungSooChung 1 ,JaeIlLee 2 ,JoongMyungCho 2 , JaeHongSeol 1 , SungHeeBaek 1 ,KeunIlKim 3 ,TomokiChiba ...
36 This probe contains the final seven amino acids of SUMO-2 with a reactive electrophile fluoromethylketone at its C-terminus, showing a preference for SENP1/2 above other cysteine proteases in labeling experiments. However, its inhibitory activity on SENP2 was twice as high compared to SENP1...
(SUMO) was found to conjugate with a number of proteins to regulate cellular functions including transcription, signal transduction,and cell cycle.While El,E2 and E3 ligases are responsible for the forward SUMOylation reaction,SUMO-specific proteases(SENPs) reversibly remove SUMO from the SUMOylated...
Plasma miR-1290 Is a Novel and Specific Biomarker for Early Diagnosis of Necrotizing Enterocolitis-Biomarker Discovery with Prospective Cohort Evaluation 热度: Regulation of the stability of RGF1 receptor by the ubiquitin-specific proteases UBP12_UBP13 is critical for root meristem maintenance ...
Sentrin/SUMO-specific proteases (SENPs) act as endopeptidases to process the pre-SUMO or as isopeptidases to deconjugate SUMO from its substrate. Here, we describe a novel quantitative FRET-based protease assay for determining the ... Jiang,Ling,Liu,... 被引量: 0发表: 2013年 Internal Cali...
Gong, L. & Yeh, E. T. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.J. Biol. Chem.281, 15869–15877 (2006). ArticleCASGoogle Scholar Gostissa, M. et al. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.EM...
or carcinogenesis6. SUMOylation is a dynamic process that can be reversed by a family of SUMO-specific proteases (SENPs)7. Six SENP members in mammals, identified with different subcellular locations and substrates, play important roles in the control of various cellular events7. SENPs, by act...
Sentrin/SUMO-specific proteases (SENPs) cleave inactive or pro form of SUMO at the C-terminus via its hydrolase activity to expose two glycine residues and thereby generating active or mature SUMO (Fig. 1B) [4], [17], [18], [19], [20], [21]. In addition to C-terminal proteolytic...
Modification in reverse: the SUMO proteases. SUMOs (small ubiquitin-like modifiers) are ubiquitin-related proteins that become covalently conjugated to cellular target proteins that are involved in a ... D Mukhopadhyay,M Dasso - 《Trends in Biochemical Sciences》 被引量: 1025发表: 2007年 Modificati...
SUMO conjugation emerges as an important mechanism in regulating protein localization, stability and activity. SUMOylation is a dynamic process and can be reversed by a family of sentrin/SUMO-specific proteases (SENPs). However, the biological roles of SENPs in cellular processes are largely unknow...