This suggests the possibility that the sulphonyl-ureas have their action not primarily on the β cells, but on insulin itself by forming a complex with it and thus altering its action. In this way the hyperglycaemic action of insulin (mobilization of glycogen, gluconeogenesis, and stimulation ...
Define sulphonylureas. sulphonylureas synonyms, sulphonylureas pronunciation, sulphonylureas translation, English dictionary definition of sulphonylureas. These reduce the levels of glucose in the blood and are used to treat diabetes mellitus. Dictionary
Although some endogenous insulin secretory capacity seems to be necessary for Sulphonylureas to be effective (they are ineffective in pancreatectomised animals), their precise mechanism of action has not been clear. Short-term administration of Sulphonylureas to animals or humans is associated with...
Fuhlendorff J, Carr RD, Kofod H, et al. The mechanism of action of repaglinide differs to sulphonylureas in murine β-cells [abstract]. Pharmacol Res 1995; 31 Suppl. 1: 32Fuhlendorff, J. , Carr, R. , Kofod, H. & Rorsman, P. ( 1995a ). The mechanism of action of repaglinide...
(Ia) caused no damage to soya at an application rate of 8 g/ha. MECHANISM OF ACTION : None given.HILLS, MARTINKRAEHMER, HANSJOERGDIETRICH, HANSJOERGWALDRAFF, CHRISTIANFEUCHT, DIETERMUELLER, KLAUS-HELMUTPHILIPP, ULRICH