This chapter describes the chemistry, mechanism of action, pharmacodynamics, pharmacokinetics, kinetics鈥揺ffect relations, clinically beneficial and adverse effects of sulfonylurea drugs, as well as the efficacy of these agents in randomized-controlled clinical trials and other studies. It also compares ...
Houghton PJ, Sosinski J, Thakar JH, Houghton JA: Diarylsulonyluras: new anticancer agents with novel activities, toxicities and mechanism of action. Proc. Int. Congress on neoadjuvant chemotherapy. In: Banzet P, Holland JF, Kayat D, Weil M (eds) Neo-adjuvant Chemotherapy. Springer Verlag, ...
7.There are differences in mechanism of action certainly but the bottom line is that we know it works as well as sulfonylureas and I believe that has been the consensus from clinical experience. 两类药物的作用机制是不同的,但至少我们知道DPP - 4抑制剂和磺脲类同样有效,我想这也是临床经验得到的...
The introduction of the new medications prompts a reevaluation of the therapeutic role of sulfonylureas.Le texte complet de cet article est disponible en PDF. Plan MECHANISM OF ACTION Beta Cell Receptors Extrapancreatic Receptors Additional Effects of Sulfonylurea TREATMENT OF NIDDM WITH SULFONYLUREAS ...
The elucidation of the mechanism of action of herbicides such as the sulfonylureas not only has implications on the rational design of herbicides but also ... Ray,B Thomas - 《Trends in Biochemical Sciences》 被引量: 121发表: 1986年 Sulfonylureas: New High Potency Herbicides Sauers R F,Levitt...
Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C. Hypoglycemic sulfonylureas stimulate insulin release by binding to a regulatory subunit of plasma membrane ATP-sensitive K+ (K(ATP)) channels. The conseque... YA Ti...
Sulfonylureas as second-line drugs are associated with an increased risk of severe hypoglycemia79, and our study is in support of this. The hypoglycemic effect of sulfonylureas might be due to its insulin-dependent mechanism of action, while the less hypoglycemic effect of SGLT2Is is due to the...
The NLRP3 inflammasome is activated by fibrillar Syn via a Syk kinase dependent mechanism, and also occurs in the absence of Syn pathology at the early stages of dopaminergic degeneration, and drives neuronal loss. The compounds of the first aspect may block NLRP3 inflammasome activation by ...
The adsorption behavior and mechanism of eight sulfonylurea herbicides on humic acid (HA) was studied with the method of batch equilibrium and the technique of Fourier transform infrared (FT-IR) was used to observe its sorption mechanism. 结果表明,腐植酸对8种磺酰脲除草剂的吸附作用较强,其吸附强...
Febbraio, “Role of interleukins in obesity: implications for metabolic disease,” Trends in Endocrinology and Metabolism, vol. 25, No. 6, pp. 312-319, (Jun. 2014). Guo, et al., “inflammasomes: mechanism of action, role in disease, and therapeutics,” Nature Medicine, vol. 21, No....