Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residuesdoi:10.14814/phy2.12533ATP-sensitive K+ channelsDiazoxidefunctional couplingATP-sensitive potassium channels (K-ATP channels) play a key role in adjusting the membrane potential...
Oral hypoglycemic sulfonylurea agents: newer aspects of their mechanism of action and clinical usage 来自 ResearchGate 喜欢 0 阅读量: 11 作者: H Lebowitz 收藏 引用 批量引用 报错 分享 全部来源 求助全文 ResearchGate 相似文献Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human ...
Figure 6. KATP channel drugs glibenclamide and diazoxide do not improve surface expression of the L1544P-SUR1 mutant channel. Cells expressing wild-type or mutant channels were treated with 5 μm glibenclamide or 100 μmdiazoxide for 24–48 h, and surface expression of channels were measured ...
acidandcitratewerefoundtoberesponsiblefortheseparation ofT2DMandSU-treatedgroups,whichindicatesapotentialeffectofSUonenergymetabolism,Tricarboxylicacid(TCA)cycle, gutmicroflorametabolismandoxidativestress.Thestudymaybehelpfultotheunderstandingoftheactionofmechanismof SUantidiabeticdrugs.Copyright©2014JohnWiley&Sons,...
Rather, exenatide may influence weight loss mainly through energy restriction by a mechanism similar to GLP-1 [30, 31], i.e. 2 centrally mediated regulation of appetite, satiety and food intake. It may therefore be associated with health benefits similar to those of a diet therapy. Recent ...
Kanda Y, Matsuda M, Tawaramoto K, Kawasaki F, Hashi- ramoto M, Matsuki M, and Kaku K: Effects of sulfonyl- urea drugs on adiponectin production from 3T3-L1 adi- pocytes: implication of different mechanism from piogli- tazone. Diabetes Res Clin Pract. 2008; 81: 13-18...
The hypoglycemic sulfonylurea drugs cause reduction of blood glucose predominantly via stimulation of insulin release from pancreatic beta cells. In addition, during long-term treatment, an insulin-independent blood glucose-decreasing mechanism is assumed to operate. This may include insulin-sensitizing and...
The sulfonylurea is known to regulate blood glucose homeostasis but have a characteristic profile of side effects. Some medicinal plant have showed hypoglycemic activities but the exact mechanism of action of these drugs at cellular level is yet not known and thus no better formulation of indigenous...
This interaction could account, at least in part, for the synergistic effects of incretin-related drugs and sulfonylureas in insulin secretion. Accordingly, clarification of the mechanism of Epac2A activation may provide therapeutic strategies to improve insulin secretion in diabetes....
Their mechanism of action is unknown but does not appear to be the result of nonselective destruction of actively dividing cell populations. Mitochondria have been shown to accumulate Sulofenur and therefore may be targets of drug action. The purpose of these investigations was to examine the ...