Our study suggests that might be made channel-specific for acetolactate but not for acetohydroxybutyrate. We postulate specific physiological roles for and III to support under conditions that vary the levels and balance of substrates.doi:10.1006/bbrc.1995.1151P.A. Herring...
Using rigid-body docking (Supplementary Fig.6a), we disambiguated the four-fold degeneracy of the fluorines and assigned the measured dipolar couplings to specific protein amide protons (Supplementary Tables2and3). For weak REDOR dephasing that corresponds to distances longer than 10 Å, four c...
Earlier studies proved that Pseudomonas aeruginosa OprD is a specific porin for basic amino acids and imipenem. It was also considered to function as a nonspecific porin that allowed the size-dependent uptake of monosaccharides and facilitation of the uptake of quinolone and other antibiotics. In the...
the mechanism by which a ubiquitin chain is formed on the substrate remains elusive. Here we demonstrate how substrate binding can induce a specific RING topology that enables self-ubiquitination. By analyzing a catalytically trapped structure showing the initiation of TRIM21 RING-anchored ubiquitin cha...
Before discussing the specifics of the three types of vapor processes, this chapter covers the fundamentals that all of the processes share. These include the transfer of atoms across a vacuum via the kinetic theory of gases and typical film microstructures. Under special conditions, single crystal...
Significantly and unexpectedly, we identified antibiotic-specific phenotypes associated with novel TolC mutations, suggesting that substrate specificity may not be determined solely by the transporter protein or the PAP, but may reside at least partially with the TolC-channel. Furthermore, some of the ...
A technique has been devised which optimally demonstrates non-specific esterase activity in human blood lymphocytes. The reaction is carried out on smears ... KE Higgy,GF Burns,FGJ Hayhoe - 《Scand J Haematol》 被引量: 50发表: 2010年 Cumulative biochemical effects of repeated subclinical hydrogen...
The active site of CYP154C5 forms a flattened hydrophobic channel with two opposing polar regions, perfectly resembling the size and polarity distribution of the steroids and thus resulting in highly specific steroid binding with Kd values in the range 10–100nM. Key enzyme–substrate interactions ...
To determine if this were the case on our task, we used an independent face–place localizer (see the subsection “Face–Place Localizer” in the “Methods” section) to identify participant-specific face- and place-selective fROIs (Fig. 4a). Neither fROI showed significant encoding of the ...
D. Genetic control of neuronal activity in mice conditionally expressing TRPV1. Nat. Methods 5, 299–302 (2008). Article CAS Google Scholar Guler, A. D. et al. Transient activation of specific neurons in mice by selective expression of the capsaicin receptor. Nat. Commun. 3, 746 (2012...