Sub-therapeutic doses of sirolimus and cyclosporin A in combination reduce SLE pathologies in the MRL mouse. Inflamm Res 44 Suppl 2:S205-206.Warner LM, Cummons T, Nolan L, Sehgal SN (1995) Sub-therapeutic doses of sirolimus and cyclosporin A in combination reduce SLE pathologies in the ...
Antibiotics given at low doses to animals have the notable effect of increasing weight—a practice termed sub-therapeutic antibiotic treatment (STAT) and used since 1946 in livestock [15]. Experiments showing that the effect of STAT is lost in germ-free chicks indicated, more than 50 years ...
Results: the meanings given by the participants were grouped into four thematic categories: a) from the crisis(es) to the psychiatric hospital: itineraries of loss, prejudice and mistreatment; b) trajectories in the substitutive network: advances in mental healthcare; c) significant social actors...
Each patient received a median of three doses of MaaT013 (range, 1-3) and treatment-based responses were observed seven days after each administration and 28 days after administration of the first dose. Nine patients achieved a complete response (CR), 6 a very good partial response (VGPR)...
Levodopa daily doses were significantly reduced by 45%, 36% and 28% at 12, 24 and 36 months post-surgery. 14 patients (15%) developed postoperative hemichorea-ballism which required pallidotomy in eight. These 14 patients had significantly higher dyskinesia scores (levodopa induced) preoperative...
The permeability of average skin to benztropine is in the range of 70 to 90 μg/cm2/hr, and systems as described above can deliver benztropine in vivo at therapeutically useful rates of 10 to 40 μg/hr. The size of the device can be selected to provide daily doses of about 0.4 to ...
The rate of the composite endpoint of MB or CRNMB was 6.9 per 100 person/months in patients who had been given prophylactic doses, and 26.4 per 100 persons/months in those who had been prescribed higher doses (HR 3.89; 95%CI, 1.90 to 7.97). The corresponding rates for overall ...
Method for combining sub-therapeutic dosesA method is disclosed for selecting ingredient subsets for evaluation. The method receives a selection of at least one primary clinical effect and selects a plurality of ingredients that have the at least one primary clinical effect. In addition, the ...
In case of combination of sub therapeutic doses of simvastatin and glipizide, the fall in blood glucose level was gradual and sustained and it reached up to 201.5 mg/dl by the 30th day (P 0.001). These observations are comparable with the results obtained in case of glipizide treated rats,...
Molhoek, Kerrington R.Brautigan, David L.McSkimming, Chantel C.Olson, Walter C.Slingluff, Craig L.Journal of ImmunotherapyMolhoek K, Brautigan D, McSkimming C (2006) Regulatory T cells are selectively destroyed by treatment with sub-therapeutic doses of sirolimus or sorafenib....