This potential target could be attained by using therapeutic drug monitoring (TDM), i.e. adjusting the dose based on measured plasma trough concentrations. Hypothetically, this will increase mPFS, but this has not yet been evaluated in a randomized controlled trial (RCT). There...
Therapeutic Level IV.Various scientific studies and research papers have been produced to illuminate the workings of the coronavirus disease 2019 (COVID-19) pandemic and its prolonged effects on the human form. COVID-19's reach extends to several organs, notably the female reproductive system. ...
Inverted U-shaped dose-response curve of the anxiolytic effect of cannabidiol during public speaking in real life. Front Pharmacol. 2017;8:259. doi:10.3389/fphar.2017.00259 10. Sholler DJ, Schoene L, Spindle TR. Therapeutic efficacy of cannabidiol (CBD): a review of the evidence ...
24,25,48,50 This pattern of muscle hypertrophy without improved function has been seen in other pharmacotherapeutic approaches as well, including agents that target other receptor pathways, such as selective androgen receptor modulators.51 Mixed results have also been reported with testosterone treatment...
using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a track record of success with two approved medicines, including AYVAKIT®/AYVAKYT®...
use of fraction of the therapeutic dose and the threshold of toxicological concern (TTC), as well as health-based exposure limits (HBELs) are applied... SB Bandara,A Urban,LG Liang,... - 《Regulatory Toxicology & Pharmacology》 被引量: 0发表: 2021年 Deriving harmonised permitted daily expo...
Reversal of dabigatran with idarucizumab in stroke patients appears easy to manage, safe and beneficial. The SOPs aim to reassure stroke physicians to include dabigatran reversal into their daily clinical routine when dealing with patients presenting with acute stroke under dabigatran therapy. ...
This randomized clinical trial evaluates the effects of therapeutic-dose low-molecular-weight heparin vs standard prophylactic or intermediate-dose
Validity of the Minnesota Living With Heart Failure questionnaire as a measure of therapeutic response to enalapril or placebo. Am J Cardiol. 1993;71(12):1106-11078475878PubMedGoogle ScholarCrossref 13. Müller-Nordhorn J, Roll S, Willich SN. Comparison of the Short Form (SF) 12 health ...