It has been plagued with diagnostic and therapeutic challenges due to lack of appropriate facilities, definitive diagnosis and interventions in resource-poor African centres. It typically presents with progressive HF and is associated with high mortality. In one study, the 4-year mortality was found ...
2 Cardiac myosin inhibitors (CMIs) have been developed as a therapeutic option for patients with obstructive HCM by targeting the underlying etiopathology of the disease. They act by directly reducing excessive actin-myosin crossbridges at the level of the sarcomere and mitigate cardiac ...
or “YLLs”) to rank health conditions in terms of their “disease burden” at a population level [39]. The 1990 GBD study that attributed more than 10% of DALYs to
Meaning This study’s findings may have implications for clinical practice and health policy regarding pediatric COVID-19 in African countries; given their high risk of adverse outcomes, COVID-19 vaccination and therapeutic interventions are needed for African children and adolescents. Abstract Importance...
A direct comparison of selective BH3-mimetics reveals BCL-XL, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma Despite advances in the treatment of neuroblastoma, patients with high-risk disease still have dismal survival prognosis. Neuroblastoma cells display elevated expression of th...
It definitely can be but mainly for the songs I write for myself, it’s therapeutic in the sense that I build this parallel universe for myself. I do take a lot of pride in the poetry I expand on in my lyrics and the world I create in my music videos, but the music aspect of ...
Therapeutic or Preventive Procedure, Laboratory Procedure, Health Care Activity, Research Activity, Activity 6 Medical Device and Object Medical Device, Manufactured Object 2 Observation Finding, Sign or Symptom, Injury or Poisoning, Laboratory or Test Result, Phenomenon or Process 5 Pathology Disease or...
20% to 50% of gangliogliomas of the brain [62,64]. Pilocytic astrocytomas make up 20% of pediatric brain tumors and appear to have about a 9% rate ofBRAFV600Emutation [65]. This mutation was found to be associated with extracerebellar location. The therapeutic implications ofBRAFmutations...
s innervating different targets, and within these different fibre types, all representing distinct physiological roles. While some studies have developed cuffs with electrode arrays designed to stimulate portions of the nerve, these have relied on the use of larger nerves with more limited therapeutic ...
Marked variations by subtype, age and sex were demonstrated; confirming that ‘real-world’ data are required not only to better inform aetiological hypotheses and plan future health-care services, but also to monitor the impact of therapeutic changes at the population level. References Al-Refaie ...