免疫荧光证实CTRL PD-L1主要位于细胞膜上(图6B,白色箭头),相反,sgFAT4PD-L1信号在细胞质检测到(图6B,红色箭头),膜上信号减少。流式细胞术显示,FAT4过表达显著降低PD-L1细胞膜表达(图6E)。作者进一步研究FAT4过表达在体外以β-...
STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nat Commun. 2018;9(1):9.J. Hsu, W. Xia, Y. Hsu et al., "STT3-dependent PD-L1 accumu- lation on cancer stem cells promotes immune evasion," Nature Communications, vol. 9, no. 1, article 1908, 2018....
4.免疫治疗: 针对某些特殊病例,可能会推荐免疫检查点抑制剂如PD-1/PD-L1抑制剂。 尿路上皮癌的治疗需要根据个体情况进行综合评估。定期随访和监测是避免复发的重要措施。2024-12-19
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单位 笔记 接收特定网络阳离子 参数 光纤 灵敏度 最大输入功率 信号检测断言 信号检测,拉高 信号检测滞后 工作波长 - P in Pa Pd - -7 - -47 1.0 1100 - - - - - - -34 - -34 - 4.0 1600 DBM DBM DBM DBM dB nm 测量转换:从低到高 测得的过渡:前高后低 测量2 23 -1 PRBS 72 1和 72...
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(AXIN1, APC, GSK3β, CK1); (ii) FAT4 inhibits PD-L1 and STT3A transcription in a β-catenin-dependent manner and induces aberrant PD-L1 glycosylation and ubiquitination-dependent degradation; (iii) Promotes activation of cytotoxic T lymphocytes (CTL) and infiltration into the tumor ...
PD-L1Immune evasionCancer stem cells (CSCs) are considered to mediate tumorigenesis, recurrence, and metastasis. KYA1797K, a β-catenin inhibitor, has been identified for its functionality as a tumor suppressor gene in colorectal cancer through inhibition of the Wnt/β-catenin signaling pathway. ...