structure-function relationshipThe La-related proteins (LaRPs) are an ancient superfamily of RNA-binding proteins orchestrating the major fates of RNA, from processing and maturation to regulation of mRNA translation. LaRPs are instrumental in modulating complex assemblies where the RNA is bound, ...
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We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
The Nsp3 of HCoV NL63 as a representative of alpha-CoVs, and of SARS-CoV in clade B of the genus beta-CoV, are zoomed out. The question mark within HCoV-NL63 Nsp3 indicates a region of unknown function and structure. (B) Summary of the functions and domain organization of SARS-CoV...
Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological relevance. H
and function of TRP channels and summarize their different types, focusing on their key roles in various physiological and pathological conditions, particularly in pain, inflammatory bowel disease (IBD) and its complications, respiratory diseases, neurological disorders, and cardiovascular diseases (CVDs)....
are usually used,and the site choosing of the targeted mRNA play a very important role in the RNAi.One of the causes is that mRNA has complex secondary structures.The relations between the secondary structures of mRNA and siRNA activity from some published data of experiment is tried to find....
Requirement for a Uroplakin 3a-Like Protein in the Development of Zebrafish Pronephric Tubule Epithelial Cell Function, Morphogenesis, and Polarity Uroplakin (UP)3a is critical for urinary tract development and function; however, its role in these processes is unknown. We examined the function of the...
The density of predicted intronic RNAs increases with the length of introns, and the density of predicted secondary structures within mRNA coding regions increases with the number of introns in a gene. CONCLUSIONS/SIGNIFICANCE: There are many conserved, high-confidence RNAs of unknown function in ...
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