The new data concerning the structure of nuclear receptor of thyroid hormone and peculiarities of its functioning as a ligand--dependent transcriptional factor are reviewed. Considerable attention is concentrated on the analysis of mechanisms of receptorAF Nazarova...
Structure of the hormone binding domain of human .beta.1 thyroid hormone nuclear receptor: Is it an .alpha./.beta. barrel? To understand the structure of the hormone binding domain (HBD) of human beta 1 thyroid hormone nuclear receptor (h-TR beta 1), truncated h-TR beta 1 fragm... ...
Novel insights on thyroid-stimulating hormone receptor signal transduction. The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of family A G protein-coupled receptors. The TSHR is of great import... Gunnar,Kleinau,Susanne,... - 《Endocrine Reviews》 被引量...
1 The iodine cycle in the thyroid gland and the chemistry of thyroid-hormone formation. a, Iodide is extracted from the blood vessels and into the thyroid cells via the Na+ and I− symporter. TSH binds TSH receptor (TSHR) to induce the expression of TG. TG is secreted into the ...
The molecular regulation of IGFBP-3 in esophageal epthelial cells Membrane Protein - Structure and Function Structure of Thyroid Hormone ReceptorRecently added grants: Modulation of respiratory melioidosis inflammation Core A: Administrative Core Core B: Community Engagement Core (CEC) Treasure Your Exce...
The thyrotropin (thyroid-stimulating hormone or TSH) receptor is an amphiphilic membrane component with a relative molecular mass of about 200,000 as judged by gel filtration and an isoelectric point close to pH 5. Analyses with chemical, enzymic and affinity probes indicate that the receptor is ...
et al. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol. Endocrinol. 21, 2919–2928 (2007). 52. Jouravel, N. et al. Molecular basis for dimer formation of TRb variant D355R. Proteins 75, 111–117 (2009). ...
The TSH Receptor The thyroid-stimulating hormone (TSH) receptor (TSHR) plays a key role in the control of thyroid growth and function. This G-protein-coupled receptor essentially activates adenylate cyclase and to a lesser extent phospholipase C. The rol... M Misrahi,E Milgrom - Springer Ber...
(retinoids and thyroid hormone). It also includes a growing number of structurally related proteins for which their ligands have yet to be identified, referred to as “orphan receptors,” or members that have lost ligand binding function (e.g., thyroid hormone receptor al and α3; TRα2 ...
Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Silencer elements, by analogy to enhancer elements, function independently of their position and orientation. We show that the chicken lysozyme silencer S-... A Baniahmad,C Steiner,AC ...