严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)继续适应群体免疫背景并进化成许多亚变体。 中国科学院微生物研究所高富(George Fu Gao)教授实验室揭示了新发现的SARS-CoV-2亚型BA.2.86、j .1、EG.5、EG.5.1和HV.1亚型的刺突(S)蛋白结构,并对这些亚型进行了系统的比较分析。研究结果发表在《结构》杂志上。
Since the proteins of SARS-CoV-2 play vital role in the life cycle and structure of the virus, thus this study divides all of the SARS-CoV-2 proteins into three classes: Structural proteins, Non-Structural proteins, and accessory proteins. Herein, the structure and function of SARS-CoV-2 ...
近日,南方科技大学王培毅团队与牛津大学Peijun Zhang团队合作从临床患者体内分离新冠病毒,通过β-丙醇酸内酯灭活病毒,利用冷冻电镜和冷冻电子断层扫描技术解析了完整SARS-CoV-2颗粒上的刺突蛋白结构,为理解生理条件下膜融合前后刺突蛋白的构象提供了更加精确...
近日,南方科技大学王培毅团队与牛津大学Peijun Zhang团队合作从临床患者体内分离新冠病毒,通过β-丙醇酸内酯灭活病毒,利用冷冻电镜和冷冻电子断层扫描技术解析了完整SARS-CoV-2颗粒上的刺突蛋白结构,为理解生理条件下膜融合前后刺突蛋白的构象提供了更加精确的信息,研究成果发表在Cell子刊Structure期刊上。 标题 新冠病毒的刺...
2024 年 7 月 15 日,中国科学院微生物研究所高福院士团队在Structure上在线发表了题为「Spike structures,receptor binding and immune escape of recently-circulating SARS-CoV-2 Omicron BA.2.86,JN.1,EG.5,EG.5.1 and HV.1 sub-variants」的封面文章,报道了相关流行株的 S 蛋白自身及其与人类受体(hACE2)...
2024年7月15日,中国科学院微生物研究所高福院士团队在Structure上在线发表了题为“Spike structures,receptor binding and immune escape of recently-circulating SARS-CoV-2 Omicron BA.2.86,JN.1,EG.5,EG.5.1 and HV.1 sub-variants”的封面文章,报道了相关流行株的S蛋白自身及其与人类受体(hACE2)的复合物结...
In this study, we present the crystal structure of the C-terminal domain of SARS-CoV-2 (SARS-CoV-2-CTD) spike (S) protein in complex with human ACE2 (hACE2), which reveals a hACE2-binding mode similar overall to that observed for SARS-CoV. However, atomic details at the binding ...
2024 年 7 月 15 日,中国科学院微生物研究所高福院士团队在Structure上在线发表了题为「Spike structures,receptor binding and immune escape of recently-circulating SARS-CoV-2 Omicron BA.2.86,JN.1,EG.5,EG.5.1 and HV.1 sub-variants」的封面文章,报道了相关流行株的 S 蛋白自身及其与人类受体(hACE2)...
of infection at an atomic level, we determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 bound to the cell receptor ACE2. The overall ACE2-binding mode of the SARS-CoV-2 RBD is nearly identical to that of the SARS-CoV RBD, which ...
Structure of Hyperthermophilic Respiratory Complex III FeiLab 3 0 SARS-CoV-2 spike protein treated with cathepsin L 1 FeiLab 6 0 SARS-CoV-2 spike protein treated with cathepsin L 4 FeiLab 3 0 Unusual Homodimer of a Heme‐Copper Terminal Oxidase FeiLab 1 0 Overall architecture of mo...