近日,南方科技大学王培毅团队与牛津大学Peijun Zhang团队合作从临床患者体内分离新冠病毒,通过β-丙醇酸内酯灭活病毒,利用冷冻电镜和冷冻电子断层扫描技术解析了完整SARS-CoV-2颗粒上的刺突蛋白结构,为理解生理条件下膜融合前后刺突蛋白的构象提供了更加精确...
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)继续适应群体免疫背景并进化成许多亚变体。 中国科学院微生物研究所高富(George Fu Gao)教授实验室揭示了新发现的SARS-CoV-2亚型BA.2.86、j .1、EG.5、EG.5.1和HV.1亚型的刺突(S)蛋白结构,并对这些亚型进行了系统的比较分析。研究结果发表在《结构》杂志上。
近日,南方科技大学王培毅团队与牛津大学Peijun Zhang团队合作从临床患者体内分离新冠病毒,通过β-丙醇酸内酯灭活病毒,利用冷冻电镜和冷冻电子断层扫描技术解析了完整SARS-CoV-2颗粒上的刺突蛋白结构,为理解生理条件下膜融合前后刺突蛋白的构象提供了更加精确的信息,研究成果发表在Cell子刊Structure期刊上。 标题 新冠病毒的刺...
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant genetic shift from different isolates. Afte...
SARS-CoV和MERS-CoV作用于宿主细胞的机制 Fig.2.ComparisonoftheknownstructuresSARS-CoVRBDanditsACE2complexwiththededucedmolecularmodelsof2019-nCoVRBD.Somestructuresegmentsandkeyaminoacidresiduesareindicated.检测方法 •实验室检测：病毒分离——金标准 •分子诊断技术 •基因测序技术：二代测序宏基因组学技术、...
we determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 bound to the cell receptor ACE2. The overall ACE2-binding mode of the SARS-CoV-2 RBD is nearly identical to that of the SARS-CoV RBD, which also uses ACE2 as the cell recepto...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID19 pandemic, is a highly pathogenic β-coronavirus. As other coronaviruses, SARS-CoV-2 is enveloped, replicates in the cytoplasm and assembles at intracellular
SARS-CoV-2是一种β型冠状病毒，可导致呼吸道感染，严重者会出现死亡【1】。疫苗作为重要的防治手段，大大缓解了COVID-19大流行带来的危害，但自Omicron和 Delta等多种变异病毒的出现，致使疫苗的有效性显著下降，这也促使科学家寻找新的治疗手段来解决变异病毒的耐药性问题。至今为止，FDA已批准三种抗病毒药物，...
On the basis of the unliganded structure, we developed the lead compound into a potent inhibitor of the SARS-CoV-2 M pro . The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route. 展开 ...
SARS-CoV-2 SGFs could bind ACE2 based on previous studies [12]. In the current study, interactions between pseudotyped particles and polysaccharides from Saccharina japonica have been further investigated to elucidate their structure-activity relationship. In addition, the possible inhibitory activities ...