Unexpectedly, the crystal structure of IL-17F reveals that IL-17 family members adopt a monomer fold typical of cystine knot growth factors, despite lacking the disulfide responsible for defining the canonical 'knot' structure. IL-17F dimerizes in a parallel manner like neurotrophins, and features...
Interleukin-17A (IL-17A) is a principal driver of multiple inflammatory and immune disorders. Antibodies that neutralize IL-17A or its receptor (IL-17RA) deliver efficacy in autoimmune diseases, but no small-molecule IL-17A antagonists have yet progresse
Edited byRavindra Pratap Singh,Shyam S. Pandey,Jay Singh,Arunadevi Natarajan 26 March 2025 Molecular Structure and Mechanisms of Action of Antioxidants Edited byRui Fausto,Walter F. de Azevedo,Gülce Ögrüc Ildiz 8 November 2024 View all special issues and article collections View all issues...
K.: Simultaneous expression of 70 kilodalton type IV collagenase and type IV collagen u1 (IV) chain genes by cells of early human placenta and gestational endometrium. Lab. Invest.67: 191–200, 1992.
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Edited byRavindra Pratap Singh,Shyam S. Pandey,Jay Singh,Arunadevi Natarajan 26 March 2025 Molecular Structure and Mechanisms of Action of Antioxidants Edited byRui Fausto,Walter F. de Azevedo,Gülce Ögrüc Ildiz 8 November 2024 View all special issues and article collections View all issues...
Peripheral T cell lymphomas are typically aggressive with a poor prognosis. Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells limits the efficacy of immunotherapeutic approaches. The T cell re
Granites constitute the basement of the whole basin and the weathering profiles are easily observable through many dug wells used by the farmers for irrigation (Fig. 2). Under a few decimetres of red soils, the weathered layers with a thickness of 0 to 5 m cover the fissured zone. A ...
STRUCTURE FOR PREVENTING SEPARATION OF DUST SEAL OF TIE ROD END IN STEERING SYSTEM PURPOSE: Dust seal separation preventing structure for a tie rod end of a steering system is provided to firmly fix a dust seal and to prevent the dust sea... JUNG,IL Hwan,JI Hwan 被引量: 0发表: 2001年...
Recent breakthroughs in highly accurate protein structure prediction using deep neural networks have made considerable progress in solving the structure prediction component of the ‘protein folding problem’. However, predicting detailed mechanisms of h