2024 年 8 月 6 日,清华大学生命科学学院/北京生物结构前沿研究中心王新泉教授课题组在《结构》(Structure)杂志在线发表研究论文,题目为「人源 IL-12 信号复合物的结构与组装」(Structure and assembly of the human IL-12 signaling complex)...
2024年8月6日,清华大学生命科学学院/北京生物结构前沿研究中心王新泉教授课题组在《结构》(Structure)杂志在线发表研究论文,题目为“人源IL-12信号复合物的结构与组装”(Structure and assembly of the human IL-12 signaling complex)。该研究成果增强了对IL-12信号起始的理解,同时也为IL-12的改造和治疗应用开辟了...
8月6日,清华大学生命科学学院/北京生物结构前沿研究中心王新泉课题组在《结构》(Structure)杂志在线发表研究论文,题目为“人源IL-12信号复合物的结构与组装”(Structure and assembly of the human IL-12 signaling complex)。该研究成果增强了对IL-12信号起始的理解,同时为IL-12的改造和治疗应用开辟了新的机会。 ...
8月6日,清华大学生命科学学院/北京生物结构前沿研究中心王新泉课题组在《结构》(Structure)杂志在线发表研究论文,题目为“人源IL-12信号复合物的结构与组装”(Structure and assembly of the human IL-12 signaling complex)。该研究成果增强了对IL-12信号起始的理解,同时为IL-12的改造和治疗应用开辟了新的机会。 ...
Specific topics discussed in this article include the structure, regulation, function, receptor utilization, and role of IL-12 related cytokines in respiratory disease.doi:10.1016/B0-12-370879-6/00482-8M.J. WalterWashington University School of Medicine, St Louis, MO, USAEncyclopedia of Respiratory...
541550-19-0 分子式(Formula) C23H26N6O2 分子量(Molecular Weight) 418.49 外观(Appearance) 粉末 纯度(Purity) ≥98% 溶解性(Solubility) 溶于DMSO 结构式(Structure) 运输和保存方法 冰袋运输。粉末直接保存于-25~-15℃,保持干燥,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。 注意事项 1. ...
https://www.cusabio.com/c-20630.html#:~:text=Interleukin%20is%20a%20kind%20of,a%20solid%20structure%20and%20function. https://mp.weixin.qq.com/s/_x83HGtWXqbW1tSZ-jULVQ Interleukins in cancer: from biology to therapy. Nat Rev Cancer. 2021 Jun 3 : 1–19. ...
We present a crystal structure of the quaternary IL-23 (IL-23p19/p40)/IL-23R/IL-12Rβ1 complex, together with cryoelectron microscopy (cryo-EM) maps of the complete IL-12 (IL-12p35/p40)/IL-12Rβ2/IL-12Rβ1 and IL-23 receptor (IL-23R) complexes, which reveal “non-canonical” ...
There was, however, no apparent defect in thymic structure and thymocyte development in young IL-12(-/-) mice. These results suggest the importance of IL-12 in maintaining thymic integrity and function during the aging process. Surprisingly, in WT B6 mice, there was no age-related decrease ...
This is followed by three contributions describing the structure of the IL-12 receptor and its role in determining the early events in the differentiation of T cell subsets. The modulation of IL-12 activities by other cytokines such as TGF-Beta, IFN-Gamma and IL-4 is also addressed. IL-12...