The three-dimensional structure of human insulin-like growth factor-I has been determined through a combination of NMR measurements and distance geometry calculations. A total of 320 interatomic distance constraints, including 12 related to the disulfide bridges, were used in these calculations. The ...
The three-dimensional structure of human insulin-like growth factor (IGF) II in aqueous solution at pH 3.1 and 300 K has been determined from nuclear magnetic resonance data and restrained molecular dynamics calculations. Structural constraints consisting of 502 NOE-derived distance constraints, 11 dih...
X-ray structure of human relaxin at 1.5 Å—Comparison to insulin and implication for receptor binding determinants. J. Mol. Biol. 221 :15–21 (1991).Eigenbrot, C., M. Randal, C. Quan, J. Burnier, L. O’Connell, E. Rinderknecht and A. A. Kossiakoff. (1991): X-Ray structure...
Here we determined the cryo-electron microscopic structures of human SMSr in complexes with ceramide, diacylglycerol/phosphoethanolamine and ceramide/phosphoethanolamine (CPE). The structures revealed a hexameric arrangement with a reaction chamber located between the transmembrane helices. Within this structure...
Inferences from genetic association studies rely largely on the definition and description of the underlying populations that highlight their genetic similarities and differences. The clustering of human populations into subgroups (population structure)
Boehm, K.D., Kelley, M.F. and Ilan, J.: Expression of insulin-like growth factors by the human placenta. In, Molecular and Cellular Biology of Insulin-Like Growth Factors and Their Receptors. D. Leroith and M.K. Raizada, eds., pp. 179–193. Plenum, New York, 1989a. ...
organs containing differentiated hormone-secreting cells, such as the anterior pituitary gland and pancreatic islets of Langerhans, but also in numerous other tissues spread throughout the human body, for example, fat, muscle, and intestine. This significantly widens the definition of an endocrine ...
EM studies revealed the presence of microvilli. Immunoperoxidase staining using specific anti-human Tg antisera indicated the presence of Tg within the cells... B.,Estour,A.,... - 《Virchows Archiv B Cell Pathology Zell Pathologie》 被引量: 201发表: 1989年 Sudan I induces genotoxic effects ...
Role of insulin-like growth factor-1 on the kinetics of human lymphocytes stimulation in serum-free culture medium In a serum-free medium addition of insulin-like growth factor-1 (IGF-1) consistently enhanced lymphocyte proliferation response to PHA in a dose-dependent ... R Schillaci,CM Ribaud...
Ion mobility (IM) mass spectrometry provides structural information about protein shape and size in the form of an orientationally-averaged collision cross-section (CCSIM). While IM data have been used with various computational methods, they have not yet been utilized to predict monomeric protein ...