This chapter describes structure and function of the insulin receptor. Insulin is commonly referred to as an "anabolic" hormone as it stimulates a variety of synthetic pathways. These various processes occur in distinct cellular compartments and in each case insulin exerts its effect by controlling ...
Insulin is a small globular protein containing two chains, A (21 residues) and B (30 residues) (Fig. 2.1A). Stored in the β cell as a Zn2+‐stabilized hexamer, the hormone dissociates in the bloodstream to function as a Zn2+‐free monomer (Fig. 2.1B). The structure of the free...
This chapter discusses the insulin-like peptides: structure, signaling, and function. Insulin-like peptides (ILPs) are paragons for the conservation of hormone structure and function among invertebrates and higher animals. They are encoded by multiple, distinct genes within each species and, upon ...
R. Adaptors for clathrin coats: structure and function. Annu. Rev. Cell Dev. Biol. 20, 153–191 (2004). CAS PubMed Google Scholar Kandror, K. V., Stephens, J. M. & Pilch, P. F. Expression and compartmentalization of caveolin in adipose cells: coordinate regulation with and ...
Chemistry, structure and function of insulin and related hormones. De Gruyter, Berlin, pp 425-431 21. Dodson GG, Cutfield S, Hoenjet E, Wollmer A, Brandenburg D (1980) Crystal structure, aggregation and biological potency of beef insulin cross-linked at A1 and B29 by diaminosuberic acid...
Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiological
For more than half a century insulin has occupied a position as the most intensively studied mammalian hormone. This stems in part from insulin’s role as the preeminent anabolic hormone in mammals. The effort put into understanding the physiology and biochemistry of this peptide follows a rich ...
Hubbard SR, Till JH: Protein tyrosine kinase structure and function. Annu Rev Biochem. 2000, 69 (1): 373-398. 10.1146/annurev.biochem.69.1.373. Article CAS PubMed Google Scholar De Meyts P, Whittaker J: Structural biology of insulin and IGF1 receptors: Implications for drug design. Natu...
Receptor biochemistry and methodology, vol. 12: Insulin receptors, part A: Methods for the study of structure and function; and part B: Clinical assessment, biological responses and comparison to the IGF-1 receptor: edited by C. R. Kahn and L. C. Harrison, Alan R. Liss, 1988. $96.00 ...
Structure and properties of insulin 2.7.2 Short-acting (regular) insulin formulation The short-acting insulin is also called soluble insulin or regular insulin and these formulations are dispensed as clear solutions at neutral pH. These contain zinc chloride for stability of insulin hexamers. The dim...