More than fifty years after the discovery of insulin, its cellular mechanism of action still remains one of the major obstacles in cell biology. Recent progress in the molecular characterization of the insulin receptor itself due to concerted efforts in
Knowledge of the conformation of insulin during its complex life cycle of biosynthesis, storage, receptor binding, and degradation may play an important part in the proper design of orally administered analogues, competitive inhibitors, and insulins with selectively enhanced biological activity....
For this reason, experimental animal models have been created in order to understand the pathogenesis of the disease, to examine and improve the disease prevention and treatment opportunities. In this review, the structure and functions of insulin, which causes diabetes in deficiency and low release...
Insulin - structure, function, design 喜欢 0 阅读量: 45 作者: E Hasche 摘要: Successful treatment of diabetic patients with insulin took place over 30 years without knowing the chemical structure of the hormone. Based on the primary structure and the three-dimensional architecture of the molecule...
Last two decades of structure–function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiologi... MW Szkudlinski - 《Frontiers in Endocrinology》 被引量: 9发表: 2015年 The Structure and Development of Young Children's Self-Concepts and Relati...
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Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiological
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Receptor biochemistry and methodology, vol. 12: Insulin receptors, part A: Methods for the study of structure and function; and part B: Clinical assessment, biological responses and comparison to the IGF-1 receptor: edited by C. R. Kahn and L. C. Harrison, Alan R. Liss, 1988. $96.00 ...