Dyneins: molecular structure and cellular function. Annu. Rev. Cell Biol. 10:339-372.Holzbaur,ELF,Vallee,RB.Dyneins: molecular structure and cellular function. Annual Review of Cell Biology . 1994Holzbaur, E. L. F. and Vallee, R. B. (1994). Dyneins: molecular structure and cellular ...
Peripheral insulin resistance and hyperandrogenism are the primary features of polycystic ovary syndrome (PCOS). However, how insulin resistance and hyperandrogenism affect uterine function and contribute to the pathogenesis of PCOS are open questions. W
Abstract For more than half a century insulin has occupied a position as the most intensively studied mammalian hormone. This stems in part from insulin’s role as the preeminent anabolic hormone in mammals. The effort put into understanding the physiology and biochemistry of this peptide follows a...
The structure of a spontaneously activated immune protein is determined by cryo-electron microscopy. This reveals the passage of an entire domain through a transient opening. The authors investigate the mechanism by multiple biophysical approaches. ...
The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an iideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questionsrelated to neural crest dev...
In-depth investigation of the structure-function relationship of drug delivery systems based on cell-penetrating peptides, lipid nanoparticles and polymeric colloidal, and biophysical and biochemical stability of peptide, protein, monoclonal antibody, and vaccine, as the integrative efforts on drug product...
Recent years have seen tremendous breakthroughs in structure determination of G-protein-coupled receptors (GPCRs). In 2011, two agonist-bound active-state ... XD Standfuss - 《Current Opinion in Structural Biology》 被引量: 193发表: 2011年 The insulin receptor activation process involves localized...
Sansom - Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 被引量: 3216发表: 2000年 On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors. Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular ...
The recent characterization of the human insulin receptor structure and its intrinsic tyrosine kinase activity represent major advances in our understanding of the mechanism of insulin action. It is reasonable to think that the insulin-induced autophosphorylation and activation of its receptor kinase repres...
Also, at shocked conditions, the super-paramagnetic state of Li2SO4.H2O is significantly affected and remarkable reduction (10–1 to 10–7) of the saturation magnetization is found. Note that, in the case of single crystalline Li2SO4.H2O, the disordered crystal structure has been witnessed ...