Structure and specificity of antibody molecules. Philos. Trans. R. Soc. Lond. B Biol. Sci. 1975, 272, 43-51.Poljak RJ,Amzel LM,Chen BL,et al.Structure and specificity of antibody molecules. Philosophical Transactions of the Royal Society of London . 1975...
Fig 1. Antibody structure diagram What are the Five Different Types of Antibodies There are five immunoglobulin classes of antibody molecules found in serum: IgG, IgM, IgA, IgE and IgD. They are distinguished by the type of heavy chain they contain. ...
Antibody structure refers to the arrangement and composition of the molecules that make up antibodies. It includes the basic structure of heavy and light chains, as well as the variable and constant regions. The three-dimensional structure of antibodies and the presence of fragments and carbohydrates...
Successful antibody cocktail therapeutics for Ebola were generated by mixing NAbs from humanized antibodies from mice and human survivors. This indicates that NAb diversity plays critical roles in the design of antibody cocktails, and that this diversity can be achieved through various approaches. We ha...
Evaluation of spatial epitope computational tools based on experimentally-confirmed dataset for protein antigens Antibody molecules interact with antigen proteins through the epitope area, where the epitope residues are found to be discontinuous or spatial or conforma... XiaoLian,Xu,Jing,... - 《Chine...
Polyethylene glycol (PEG) is a polymer routinely used to modify biologics and nanoparticles to prolong blood circulation and reduce immunogenicity of the underlying therapeutic. However, several PEGylated therapeutics induce the development of anti-PEG a
Antibodies and antibody-derived macromolecules have established themselves as the mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure-function relationships of antibodies provides a platform for protein engineering that has been exploited to generate a wide range of ...
Antibody Structure and Function All antibody molecules have a common core structure of two identical light chains and two identical heavy chains. The four chains are connected by disulfide bonds—each heavy chain to a light chain, and the heavy chains to each other. These four chains fold to ...
- 《American Journal of Pathology》 被引量: 537发表: 1998年 Aggravation of Anti-Myeloperoxidase Antibody-Induced Glomerulonephritis by Bacterial Lipopolysaccharide Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and idiopathic pauci-immune necrotizing crescentic glomerulonephritis are ...
During B cell development and antigen-driven selection, a coordinated series of recombination events and somatic mutations generate an extraordinarily large repertoire of antibody molecules that are selected for their capacity to bind to self and foreign antigens and for different effector functions1. In...