Chemical structure of γ-globulins and antibodies. Porter,R. R. British Medical Bulletin . 1963Porter RR. Chemical Structure of Gamma-Globulin and Antibodies. Br Med Bull 1963;19:197-201.PORTER, R. R. 1963. CHEMICAL STRUCTURE OF GAMMA-GLOBULIN AND ANTIBODIES. Br Med Bull 19:197....
Immunoconjugates having the structure I-L-X are also provided where X is a cytotoxic agent. Methods for producing such compositions are also provided. A method for remitting tumor growth is provided where a therapeutic amount of an I-L-X immunoconjugate is administered to a mammal which ...
This Collection highlights a selection of recent studies published in Communications Chemistry relating to the structure, function, detection and modification of biomolecules.
Structure and catalytic activity of the SAM-utilizing ribozyme SAMURI Crystal structures of the ribozyme SAMURI reveal the alkyltransferase mechanism and showN3-modified adenosine and dealkylated cofactor in the active site, allowing for a comparison with riboswitches that bindS-adenosylmethionine but do ...
Antibody catalysis of difficult chemical transformations - Lerner, Schultz - 1993 () Citation Context ...receptor-like molecules for virtually any chemical structure, catalytic antibodies can provide the tailor-made catalysts for reactions, in which no natural counterpart exists (Schultz & Lerner, 1995...
The ribonucleoprotein (RNP) complex of Ebola virus (EBOV) is known to be a multiprotein/RNA structure, however, knowledge is rather limited regarding the a... A Groseth,JE Charton,M Sauerborn,... - 《Virus Research》 被引量: 107发表: 2009年 Live-cell imaging of Marburg virus-infected...
complement proteins to cleave C5 into C5a and C5b. C5b also binds to the cell surface and then recruits C6 through C9; these molecules form a ring structure called the membrane attack complex (MAC), which punches through the cell membrane of the invading pathogen, causing it to swell and...
Polymeric biomaterials have extensively been used in medicinal applications. However, factors that determine their biocompatibility are still not very clear. This article reviews various effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility, including ...
While much attention has focused on the poly-sulfated glycosaminoglycan chains that decorate proteoglycans, other important elements of their architecture, such as core proteins and membrane localization, have garnered less emphasis. Hence, comprehensive structure–function relationships that consider the ...
Specific receptor for the opioid peptide dynorphin: structure–activity relationships. Proc. Natl Acad. Sci. USA 78, 6543–6547 (1981). Article CAS PubMed PubMed Central Google Scholar Xu, Y. et al. Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: ...