An antibody is a Y-shaped structure which consists of two heavy chains and two light chains. Antibody function is carried out by Fab fragment and Fc region.
The crystal structure of the complex of the anti-lysozyme HyHEL-10 Fab and hen egg white lysozyme has been determined to a nominal resolution of 3.0 A. The... DR Davies,S Sheriff,EA Padlan - 《Journal of Biological Chemistry》 被引量: 1531发表: 1988年 Structure of an antibody-lysozyme...
Polyethylene glycol (PEG) is a polymer routinely used to modify biologics and nanoparticles to prolong blood circulation and reduce immunogenicity of the underlying therapeutic. However, several PEGylated therapeutics induce the development of anti-PEG a
Present understanding of the three-dimensional structure of antibody combining sites is based on X-ray diffraction studies of myeloma immunoglobulins (revi... AG Amit,RA Mariuzza,SEV Phillips,... - 《Nature》 被引量: 1816发表: 0年 Three-dimensional structure of an antibody-antigen complex. Prese...
1998 . Anatomy of an antibody molecule: Structure, kinetics, thermodynamics and mutational studies of the antilysozyme antibody D1.3 . Immunol. Rev. 163 : 45 – 57 .Braden, BC, Goldman, ER, Mariuzza, RA, Poljak, RJ (1998) Anatomy of an antibody molecule: structure, kinetics, ...
The six CDR loops, three on each of the variable domain of the heavy chain (VH) and the light chain (VL), are involved in antigen binding. Therefore, the 3D structure of the antibody determines how it interacts with an antigen and governs its binding properties. Researchers can use the ...
The class of an immunoglobulin molecule is determined by its heavy chains. The affinity of interacting domains is such a prominent feature of antibody structure that some authors define a domain as a pair of corresponding homology units folded together. However, the term domain is more commonly ...
(superscripts indicate residue numbering using the Ballesteros–Weinstein nomenclature) to improve thermostability and expression16, and N188Q in extracellular loop 2 (ECL2) to avoid glycosylation. Moreover, both a Fab fragment antibody (Fab 7881) specific for the ghrelin receptor and an antagonist, ...
A monoclonal antibody directed against the non-toxic subunit of a dimeric phospholipase A2 neurotoxin, crotoxin, neutralizes its toxicity. Crotoxin is the main toxic component of the venom of the South-American rattlesnake Crotalus durissus terrificus. It is a phospholipase A2 neurotoxin const... ...
Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Structure 8, 669–684 (2000). Article CAS PubMed Google Scholar Lange, C. & Hunte, C. Crystal structure of the yeast cytochrome bc1 complex ...