Knowledge pertaining lo antibody structure has been acquired principally from research of the last two decades. During this period many important findings have been made that are applicable to other proteins; in fact, antibodies are presently the most completely characterized of the complex proteins. ...
Immune electron microscopic localization of dinitrophenyl-modified ribosomal protein S19 in reconstituted Escherichia coli 30 S subunits using antibodies t... Escherichia coli small ribosomal subunits have been reconstituted from RNA and high performance liquid chromatography-purified proteins including protein ...
Structure and biological functions of human IgD. V. Insulin antibodies of the IgD class in sera from some diabetic patients. Insulin antibodies were detected in the sera of diabetics who had received injections of animal insulin. The incidence of anti-insulin antibodies varied fr... JJ Lertora,...
Antibody structure refers to the arrangement and composition of the molecules that make up antibodies. It includes the basic structure of heavy and light chains, as well as the variable and constant regions. The three-dimensional structure of antibodies and the presence of fragments and carbohydrates...
The distribution of antibodies in a human population is a fossil imprint of the population’s past exposure to infectious disease. If individuals’ antibody concentrations can be measured accurately, they can be used to infer both the size and timing of past epidemics. The two key post-epidemic...
Nuclear pore complexes (NPCs) mediate bidirectional nucleocytoplasmic transport of substances in eukaryotic cells. However, the accurate molecular arrangement of NPCs remains enigmatic owing to their huge size and highly dynamic nature. Here we determine
The glycoproteins, being external on the virus, are also primary targets of the humoral immune system, in which circulating antibodies are directed against viruses; many of these are neutralizing antibodies that inactivate the virus. The glycoproteins of some enveloped viruses also contain enzymatic ...
Polyethylene glycol (PEG) is a polymer routinely used to modify biologics and nanoparticles to prolong blood circulation and reduce immunogenicity of the underlying therapeutic. However, several PEGylated therapeutics induce the development of anti-PEG antibodies (APA), leading to reduced efficacy and inc...
Cellular entry of the hepatitis B and D viruses (HBV/HDV) requires binding of the viral surface polypeptide preS1 to the hepatobiliary transporter Na+-taurocholate co-transporting polypeptide (NTCP). This interaction can be blocked by bulevirtide (BLV, f
Filoviruses, including Ebola virus, pose an increasing threat to the public health. Although two therapeutic monoclonal antibodies have been approved to treat the Ebola virus disease1,2, there are no approved broadly reactive drugs to control diverse fil