Bacterial type IV secretion systems (T4SSs) are largely responsible for the proliferation of multi-drug resistance. We solved the structure of the outer-membrane core complex (OMCCF) of a T4SS encoded by a conjugative F plasmid at <3.0 Å resolution by cryoelectron microscopy. The OMCCFco...
Peptide (197 targets), Antibody (90 targets) and Nanobody (184 targets) are the sets of representative proteins. Note that a typical antibody has six CDRs, while a nanobody has three CDRs. a, Overall comparison. b, Antibody. c, Nanobody. RMSD, root-mean-square deviation. Full size ...
Antibody structure refers to the arrangement and composition of the molecules that make up antibodies. It includes the basic structure of heavy and light chains, as well as the variable and constant regions. The three-dimensional structure of antibodies and the presence of fragments and carbohydrates...
Final protein samples were either immediately frozen on cryo-EM grids or flash-frozen and used for quantification of both subunits by MS. The typical yield for an A/C tandem purification amounted to 10 µg of protein per litre of transfected cell culture. Sybody purification For the ...
Patients with typical anti–myelin-associated glycoprotein (anti-MAG) neuropathy have IgM-gammopathy, mimic distal chronic inflammatory demyelinating polyr... CJ Klein,JD Triplett,DL Murray,... - 《Neurology》 被引量: 0发表: 2024年 Anti-MAG IgM: differences in antibody tests and correlation with...
On the basis of the analysis of the stress-strain state, the most favorable structure of a wing spar from the viewpoint of minimizing the risk of stress state and providing the highest stiffness. Recommendations are given on lay-up structure stacking (compared with typical structures) for more...
The Fab fragment of the murine monoclonal antibody, MAK33, directed against human creatine kinase of the muscle-type, was crystallized and the three-dimensional structure was determined to 2.9脜. The antigen-binding surface of MAK33 shows a convex overall shape typical for immunoglobulins binding ...
The fine structure of the symbiotic alga isolated from the formainiferan Archaias angulatus (Fichtel et Moll) DeMontfort is typical of the Chlorophyceae of... JJ Lee,LJ Crockett,JH&RJ Stone - 《British Phycological Journal》 被引量: 68发表: 1974年 Histochemical studies of Ca-ATPase, succinat...
The location and configuration of the proximal cation site were very similar to those of typical peroxidases such as ascorbate peroxidase. These features may provide a structural basis for the behaviour of the radical localization/delocalization during the course of the enzymatic reaction. 展开 ...
Increasing attention has been paid to developability assessment with the understanding that thorough evaluation of monoclonal antibody lead candidates at an early stage can avoid delays during late-stage development. The concept of developability is based on the knowledge gained from the successful developm...