This drug can sterilize even latentinfectionsand has become a cornerstone of treatment for multidrug-resistant and extensively drug-resistant tuberculosis. Bedaquiline targets the mycobacterial ATP synthase, which is an essential enzyme in the obligate aerobicgenus, but how it binds the intact enzymeis ...
ATP synthases constitute a diverse collection of enzymes that are conserved in various organisms. They are located in different cellular membranes: bacterial cytoplasmic membranes, thylakoid membranes inchloroplasts, and inner membranes ofmitochondria. Structure of ATP Synthase F0 region F1 region Mechanism ...
This chapter describes the structure and function of ATP synthetase. The structure of the ATP synthase has been known longer than its function. It was first described as a tripartite unit in electron micrographs of bovine-heart mitochondria after negative staining. The tripartie unit, consisting of...
Structure of Ala24/Asp61 → Asp24/Asn61 Substituted Subunit c of Escherichia coli ATP Synthase: Implications for the Mechanism of Proton Transport and Rotary Movement in the F[sub o] Complex. 来自 EBSCO 喜欢 0 阅读量: 22 作者:Dmitriev,Oleg,Y.,Abildgaard,Frits,Markley,John,L.,Fillingame,...
ATP synthase inhibitor, Bedaquiline (Sirturo), which was approved by the FDA in 2012, was the first drug in 40 years to attack TB by a novel mechanism of action2,3,4. This marked the starting point for exploration of the mycobacterial respiratory chain as a target space for new antibiotic...
Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F 1 F 0 ATP Synthase or ATPase) is responsible for the generation of ATP through phosphory
The structure of the subunit c oligomer of the H+-transporting ATP synthase of Escherichia coli has been modeled by molecular dynamics and energy minimization calculations from the solution structure of monomeric subunit c and 21 intersubunit distance constraints derived from cross-linking of subunits....
Dudkina NV, Heinemeyer J, Keegstra W, Boekema EJ, Braun HP (2005) Structure of dimeric ATP synthase from mitochondria: an angular association of monomers induces the strong curvature of the inner membrane. FEBS Lett 579(25):5769-5772....
Das, A., and Ljungdahl, L. (1997) Composition and primary structure of the F1F0 ATP synthase from the obligately anaerobic bacterium Clostridium thermoaceticum. J Bacteriol 179: 3746-3755.Composition and primary structure of the F 1F o-ATP synthase from the obligately anaerobic bacterium ...
The similar overall structure and the high amino acid sequence homology between all known F-type ATPases indicate that the mechanism of ion translocation and catalysis as well as the mode of coupling is the same in all organisms. The simplest F0F1-type ATP synthase, e.g. that of ...