The structure of the ATP synthase has been known longer than its function. It was first described as a tripartite unit in electron micrographs of bovine-heart mitochondria after negative staining. The tripartie unit, consisting of a base-piece, a stalk and a knob was first interpreted by ...
C. (2000) Structure of the γ-ε complex of ATP synthase. Nat. Struct. Biol. 7, 1051-1054Rodgers AJ, Wilce MC. 2000 Structure of the gamma-epsilon complex of ATP synthase. Nat. Struct. Biol. 7, 1051-4. (doi:10.1038/80975)
(1988). Structure of the ATP synthase from chloroplasts studied by electron microscopy and image processing. Biochim. Biophys. Acta 933, 365-371.E.J. Boekema , M. van Heel and P. Gräber , Biochim. Biophys. Acta , 933 , 365 (1988)....
Bedaquiline targets the mycobacterial ATP synthase, which is an essential enzyme in the obligate aerobicgenus, but how it binds the intact enzymeis unknown. Here we determined cryo-electron microscopy structures ofATP synthase alone and in complex with bedaquiline. The drug-free structure suggests ...
The structure of the ATP synthase has been known longer than its function. It was first described as a tripartite unit in electron micrographs of bovine-heart mitochondria after negative staining. The tripartie unit, consisting of a base-piece, a stalk and a knob was first interpreted by ...
Described in this article are the membrane topography of subunits b, d , F 6 , OSCP and A6L of the bovine mitochondrial ATP synthase complex, and the stoichiometry of these subunits as well as of the ATPase inhibitor protein. Also described are findings regarding the regulation of the kinetics...
This review intends to summarize the structure, function and inhibition of the ATP synthase. Keywords: ATP; ATP Synthase; Electron Transport Chain; Proton motive force; Rotational Catalysis; ATP synthase Inhibition ATP: The Fuel for Life Often referred as “molecular currency” for intracellular ...
The chemical ATP, adenosine triphosphate, is the fuel that powers all life. Despite ATP's central role, the structure of the enzyme generating ATP, F1Fo-ATP synthase, in mammals, including humans, has not been determined. Now, scientists from IST Austria
Fig. 1: Rotation in ATP synthase. aATP synthase (left) consists of an F1and an FOregion with a shared rotor subcomplex (outlined in black) and a peripheral stalk (green). Rotation driven by proton translocation through the FOregion, or the opposite rotation driven by ATP hydrolysis in the...
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS is therefore emerging as a bona fide dru