Various intracellular bacteria depend on host mitochondrial function to parasitize energy and nutrients stores29. Chlamydiae, for instance, lack an F1-F0 ATP synthase for H+-driven ATP synthesis30 as well as genes for the biosynthesis of vitamins, purines, pyrimidines, and almost all amino acids...
ATP synthase contains a highly regulated, multi-conductance channel that is contained within the c-subunit ring of the main membrane bound (FO) portion (Alavian et al., 2014; Mnatsakanyan et al., 2019). Pathological opening of the channel may occur upon conformational change of the ATP synt...
Yasuo SugiyamaNew Era of BioenergeticsMukohata Y, Ihara K, Yoshida M (1991) The ATP synthase in ex- treme halophilic archaebacteria and its relatives. In: Mukohata Y (ed) New era of bioenergetics. Academic Press, Tokyo, pp 169-196
The transsulfuration pathway (TSP) is an evolutionarily conserved pathway that commits methionine to cysteine synthesis in metazoan1,2,3. There are two key enzymes, cystathionine β-synthase (CBS) and cystathionase (CTH, also called cystathionine γ-lyase, GCL), in this pathway. CBS converts ...
Since C. sticklandii possesses both pathways, a possible function of the Wood-Ljungdahl pathway may be the formation of methylene-THF from CO2, which is then used in the glycine synthase/glycine reductase pathway as described for amino acid-fermenting "acetogenic" bacteria. However, this does ...
The cell wall of Gram-positive bacteria is a complex assemblage of glycopolymers and proteins. It consists of a thick peptidoglycan sacculus that surrounds the cytoplasmic membrane and that is decorated with teichoic acids, polysaccharides, and proteins.
protomer in the L conformation.(对,O conformation is not the binding stage,L conformation is the binding stage,ADP+Pi=ATP+H2O)C. ATP binds to the protomer in the O conformation (错,ATP does not bind in O conformation)D. ATP synthase is not an enzyme droved by ...
Dean M, Rzhetsky A, Allikmets R: The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 2001, 11: 1156-1166. Article CAS PubMed Google Scholar Holland IB, Cole SPC, Kuchler K, Higgins CF: ABC proteins: from bacteria to man. 2003, Academic press: London Uk Google...
Neutrophils form the first line of innate host defense against invading microorganisms. We previously showed that F0F1 ATP synthase (F-ATPase), which is widely known as mitochondrial respiratory chain complex V, is expressed in the plasma membrane of hum
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that aggregation of monomers