Although the biochemical properties of the different isoforms are currently unknown, mutations in specific subunit isoforms have been associated with various diseases, making V-ATPases potential drug targets. V-
They form a large family of ubiquitous membrane proteins, and carry out many essential processes, such as generating the membrane potential or removing toxic ions from cells. P-type ATPases undergo large conformational changes in the ion-pumping cycle. Recent X-ray and electron-microscopy structur...
Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium tuberculosis, the main causative agent of tuberculosis. Tuberculosis-causing mycobacteria, still accounting for 1.4 million deaths annual...
L. and Argu¨ello, J. M. (2008) Structure of the two transmembrane Cu + transport sites of the Cu + -ATPases. J. Biol. Chem. 283, 29753-29759 CrossRef PubMedGonzález-Guerrero, M. , Eren, E. , Rawat, S. , Stemmler, T.L. , and Argüello, J.M. ( 2008 ) Structure of ...
Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past. However, today not only are there a number of cellular proteins t... PA Ter-Keurs HEBoyden - 《Physiological Reviews》 被引量: 0发表: 2007年 atp-induced phosphorylation of the sarcoplasmic reticulum ca...
wall loosening by expansin and signalling by plant hormones such as auxin and brassinosteroid. In addition, this Review discusses the nuanced roles, properties and interactions of cellulose, matrix polysaccharides and cell wall proteins and describes how wall stress and wall loosening cooperatively result...
essential roles in bacterial virulence and pathogenicity. By targeting bacterial virulence mechanisms instead of growth, inhibitors of T3SSs may exert less selective pressure on pathogens to develop drug resistance. Structural and functional characterization of T3SSs should facilitate mechanism-based drug ...
MLL1 as well as its major fusion partners involve numerous protein–protein interactions (PPI), which plays critical roles in regulating gene expression in normal physiology and in leukemia initiation and maintenance. Moreover, the wild-type (WT) MLL1 in the other allele has been found to be ...
[72]. Since the spore wall is thought to be the first and most direct contact point with the environment and the host cell, the SWPs have potentially crucial roles in signaling, adherence, or enzymatic interactions [73]. Further studies are required to analyze the importance of these protein...
Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active, inward directed translocation (flip) of lipids in eukaryotic membranes. The resulting lipid asymmetry potentiates the membrane and is essential for a wide range of cellular processes such as vesicle biogenesis and tr...