These structures reinforced the inherent connection between the structure and function of proteins. PDB structures convey a very static image of proteins. In 1952, Karush and his coworkers, when researching the behavior of serum albumin, found what they called “configurational adaptability” ...
Here, we present a more detailed analysis of the structure, function, and evolution of the Gdrd protein, which allowed us to describe its molecular and structural properties, its cellular function, and thus its potential, physiological implications. We also further elaborate on its evolutionary ...
Finally, the demonstration that sHIP blocks the bactericidal activity of HRG provides a plausible explanation of the function of this novel extracellular protein and putative virulence determinant. Acknowledgments We thank the SyBIT project of SystemsX.ch for support and maintenance of the laboratory-...
Huang YJ, Montelione GT (2005) Structural biology: Proteins flex to function. Nature 438: 36-37.Huang YPJ, Montellione GT, Structural biology: Proteins flex to function, Nature 438(7064):36-37, 2005.Huang YJ, Montelione GT: News and views: Structural Biology: Proteins flex to function....
I-TASSER server: new development for protein structure and function predictions. Nucleic Acids Res. 43, W174–W181 (2015). Article CAS PubMed PubMed Central Google Scholar Bates, A. D., Berger, J. M. & Maxwell, A. The ancestral role of ATP hydrolysis in type II topoisomerases: ...
variants and mutations might be associated with affecting the conformational plasticity of S protein, potentially linked to its altered affinity, infectivity, and immunogenicity. This review focuses on the current circulating variants of SARS-CoV-2 and the structure–function analysis of key S protein ...
In this Viewpoint, we begin by describing the essential features of the methods, the accuracy of the models, and their application to the prediction and understanding of protein function, both for single proteins and on the scale of whole genomes. We then discuss the important role that ...
It was shown previously that replacement of these residues by canonical ones (Leu substitution for Asp137 and Arg substitution for Gly126) results in stabilization of the coiled-coil in the middle of Tm and affects its regulatory function. Here we employed various methods to compare structural ...
structural roles, a subset of ether lipids are thought to function as endogenous antioxidants, and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Here, we review the biology of ether lipids and their potential significance in human disorders, including ...
The SCOP database clusters different proteins that performs a similarbiological functionand are evolutionarily related to a common structural organization. This common structural organization could be the full protein or only in the active center region. Therefore one can predict the f...