function when conditions are restored[1]. This experiment established the basic notion that protein structure is encoded in theamino acid sequenceand that the loss of structure leads to the loss of function, the so-called structure–function paradigm. Many proteins are able to adopt their...
Structural biology: proteins flex to function. Nature 2005;438:36-37.Huang YJ, Montellione GT: Structural biology: proteins flex to function. Nature 2005, 438(7064):36-37.Huang YJ, Montelione GT. Structural biology: Proteins flex to function. Nature. 2005; 438 :36–37....
Here, we present a more detailed analysis of the structure, function, and evolution of the Gdrd protein, which allowed us to describe its molecular and structural properties, its cellular function, and thus its potential, physiological implications. We also further elaborate on its evolutionary ...
Finally, the demonstration that sHIP blocks the bactericidal activity of HRG provides a plausible explanation of the function of this novel extracellular protein and putative virulence determinant. Acknowledgments We thank the SyBIT project of SystemsX.ch for support and maintenance of the laboratory-...
to interact with the light chain of microtubule-associated protein MAP1B24, but it is unclear whether the FW domain is important for the autophagy function of human NBR1. ILRUN was shown to interact with the transcription factor interferon regulatory factor 3 (IRF3) but it is unknown whether...
Two of the mutations have also been performed in the first and second matrix loops and the effect on UCP1 function is very similar. We conclude that the three matrix loops contribute to the formation of the gating domain in UCP1 and propose that they form a hydrophobic pocket that ...
Structural biology: Proteins flex to function. 来自 Nature 喜欢 0 阅读量: 17 作者:Huang,Yuanpeng,J.,Montelione,Gaetano,T.摘要: Discusses the characteristics of the motions of protein structures. Role of enzymes in the pre-existing dynamics and intrinsic plasticity of proteins; Areas hosting the...
This underlines the need for computational and bioinformatics methods to establish relationships between functions and structures of proteins. Previous attempts have been largely limited to examining a single protein and predicting structure and function based on its size, charge, sequence, and other ...
The SCOP database clusters different proteins that performs a similar biological function and are evolutionarily related to a common structural organization. This common structural organization could be the full protein or only in the active center region. Therefore one can predict the...
Exploiting sequence–structure–function relationships in biotechnology requires improved methods for aligning proteins that have low sequence similarity to previously annotated proteins. We develop two deep learning methods to address this gap, TM-Vec a