The role of protein structural ana- lysis in the next generation sequencing era. Top Curr Chem 2014; 336: 67-98.Yue, W.W., Froese, D.S. and Brennan, P.E. (2014) The role of protein structural analysis in the next generation sequencing era. Top. Curr. Chem. 336, 67-98 https:/...
(Fig.2d). Glutamate should also fulfill the role of binding the N-terminal free amine group of ligand proteins, but would change the shape of the pocket. We examined the impact of glutamate substitution of D654 on the binding specificity of CtNbr1 FW domain (Fig.4c). The pocket with D...
However, the role of designability in constraining the evolution of duplicates and sequence divergence is under debate [31,32•,33]. On the contrary, sequence neighborhood was shown to affect evolutionary dynamics not only of proteins [30,31,32•,33,34] but also of small collection...
C. Protein footprinting by the combined use of reversible and irreversible lysine modifications. Proc. Natl Acad. Sci. USA 91, 11904–11908 (1994). Article CAS PubMed PubMed Central Google Scholar Leitner, A. A review of the role of chemical modification methods in contemporary mass ...
Is ‘structural genomics’ a viable approach to generating useful hypotheses for the role of proteins of unknown function? A common theme among the structural genomics initiatives at Berkeley [2•], Department of Energy/Los Alamos [3•], New York [4•], Toronto [5•], and Maryland [...
Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F1–Fo coupling GPR161 structure uncovers the redundant role of sterol-regulated ciliary cA...
Proteins play a fundamental role in almost all biological processes, and their overall activity is regulated at different levels [1]. At a first level, the concentration of a particular protein in the cell is regulated through its synthesis rate (gene expression) and its degradation rate. At ...
In this review, we outline the pathway of ether lipid biosynthesis and then describe the unique structural roles played by ether lipids in mammalian cell membranes, followed by a discussion of emerging cellular functions of these lipids. Lastly, we review the current knowledge of the role of ethe...
Mtb EspA is one such secreted protein that may require the folding assistance of Mtb Dsb proteins. The single disulfide bond within Mtb EspA has been found to have an important role in disease progression in mice as well as maintaining cell wall integrity [22], highlighting a crucial link ...
1). PDI family members are abundant and play a significant role in protein folding and quality control in the calcium-rich oxidative environment of the ER [4]. The members vary in length and domain arrangement, but share the common structural feature of having at least one domain with a ...