(Fig.2d). Glutamate should also fulfill the role of binding the N-terminal free amine group of ligand proteins, but would change the shape of the pocket. We examined the impact of glutamate substitution of D654 on the binding specificity of CtNbr1 FW domain (Fig.4c). The pocket with D...
(reviewed in detail elsewhere). However, the role of designability in constraining the evolution of duplicates and sequence divergence is under debate [31,32•,33]. On the contrary, sequence neighborhood was shown to affect evolutionary dynamics not only of proteins [30,31,32•,33,...
Pagan M,Sola RJ,Griebenow K.On the role of protein structural dynamics in the catalytic activity and thermostability of serine protease subtilisin Carlsberg. Biotechnology and Bioengineering . 2009Pagan, M,Sola, R J,Griebenow, K.On the role of protein structural dynamics in the catalytic activity...
Proteins that have grossly similar structures are classified as more closely related (Andreevaet al., 2008). This plays an important role in the search and detection of homology. In the SCOP database, the amino acid sequence identity within a protein family must be at least...
The role of GTPBP10 in H89 maturation Recently, cryo-EM structures of the homologous GTPase ObgE have been solved on the native pre-50S and mature 50S LSU from E. coli39. Structures and biochemical evidence provide mechanistic insight how ObgE aids the organization of the LSU catalytic center...
Structural components of the protein plays a role in the body 翻译结果2复制译文编辑译文朗读译文返回顶部 正在翻译,请等待... 翻译结果3复制译文编辑译文朗读译文返回顶部 Protein plays a role of airframe structural components 翻译结果4复制译文编辑译文朗读译文返回顶部 ...
The H-NS protein plays a key role in condensing DNA and modulating gene expression in bacterial nucleoids. The mechanism by which this is achieved is dependent, at least in part, on the oligomerization of the protein. H-NS consists of two distinct domains; the N-terminal domain responsible ...
In this Viewpoint, we begin by describing the essential features of the methods, the accuracy of the models, and their application to the prediction and understanding of protein function, both for single proteins and on the scale of whole genomes. We then discuss the important role that ...
Structural information on the interactions of proteins with other molecules is plentiful, and for some proteins and protein families, there may be 100s of available structures. It can be very difficult for a scientist who is not trained in structural bio
Strategies for the design of drugs targeting RNA and RNA–protein complexes. Angew. Chem. Int. Ed. Engl. 39, 1890–1904 (2000). CAS PubMed Google Scholar Boehr, D. D., Nussinov, R. & Wright, P. E. The role of dynamic conformational ensembles in biomolecular recognition. Nat. Chem....