Biochemistry Chemical and structural components of specific RNA recognition UNIVERSITY OF CALIFORNIASAN FRANCISCO R. K. Guy MillsNicholas LRNA molecules fold into complex tertiary structures that dictate biological function. These RNA molecules also represent an untapped class of potential drug targets. ...
Well studied bacteriophages like T7 prevent the expression of host genes by inhibiting the host transcription machinery, and replace it with virus-encoded components that exclusively transcribe viral genes. The bacteriophage T7 factors Gp2 and P7 target the RNAP β′ subunit directly and not only i...
Circular effects in representations of an RNA nucleotides data set in relation with principal components analysis During the last few years, the main reason for using molecular structure databases has changed. Instead of using databases as a storage medium, databases n... TH Reijmers,R Wehrens,...
transfer. A pyrimidine base (U/C) at N1position will sterically clash with the side chain of Tyr132 (Fig.2h, Supplementary Fig.2f). Although all components required for methylation are present in our crystals, we have not observed methylation of 2′-OH, possibly due to lower abundance of ...
RNA 结构/功能› TechNotes› End Labeling RNA for Structural Analysis The final folded structure of an RNA dictates its association with the cellular machinery involved in processes such as transcription, translation, and splicing, and therefore is crucial for its...
Overviews of the RNase R-binding site on the 30S subunit, highlighting interactions with 30S components h40 (green), uS7 (blue), bS18 (sky blue) and uS11 (lime). For RNase R, individual domains are indicated and coloured as inb.d, Interaction of the CSD2 domain (purple) with h40 ...
Components and Levels Tested with RNaseAlert Deciphering Nuclease Digestion Data End Labeling RNA for Structural Analysis Products for RNA Structure/Function Analysis The final folded structure of an RNA dictates its association with the cellular machinery involved in pr...
Figure 1. Summary of the main concepts discussed in this review. Structural information can be used in many ways to help us retrieve the characteristic functional properties of cellular components. Here, we detail recent advances in the use of protein structures to predict protein interactions, prot...
The polysaccharides could enhance the proliferation of RAW264.7 cells to produce NO due to the increased m RNA expression of NO synthetase. The polysaccharides also could upregulate the m RNA expression of the cytokines COX-2 and TNF-α. 展开 ...
Continuous interdomain orientation distributions reveal components of binding thermodynamics. J. Mol. Biol. 430, 3412–3426 (2018). CAS PubMed PubMed Central Google Scholar Denny, S. K. et al. High-throughput investigation of diverse junction elements in RNA tertiary folding. Cell 174, 377–...