Citation:Clancy, S.(2008)Chemical structure of RNA.Nature Education7(1):60 The more researchers examine RNA, the more surprises they continue to uncover. What have we learned about RNA structure and function so far? AaAaAa Figure 1
Clancy S. Chemical Structure of RNA. Nat Educ. 2008;7(1):60.Clancy, S.: Chemical structure of RNA. Nature Education 1(1) (2008), http://www.nature.com/scitable/topicpage/chemical-structure-of-rna-348Figure 3.3.1 Chemical structure of (a) resorcinol and (b) pyrogallol ... 113Cla...
Structure of RNA RNA is the ribonucleotides that are single-stranded and are linked with the help of phosphodiester bonds. The nucleotides are the monomeric unit in the nucleic acid that is composed of three main constituents: – a five-carbon sugar, a nitrogenous base, and phosphoric acid. ...
aSecondary structure of mt-tRNACyswith modifications. “p” and “OH” stand for 5′-monophosphate and 3′-hydroxy termini, respectively. Symbols for modified nucleosides are as follows: m1G 1-methylguanosine, Ψ pseudouridine, i6AN6-isopentenyladenosine, m1A 1-methyladenosine. Watson–Crick and ...
6.11.3.2Modifications of the Sugar Modifications to theriboseprovide a remarkable level of control over the sugar conformation in the nucleotide, which determines the ON’s binding affinity toward its complementary strand and duplex structure. Sugar puckering can be altered through gauche andanomeric eff...
Chemical probing is a powerful technique to examine RNA structure in solution. • Dimethyl sulfate probing identifies different conformational states under different solution conditions. • Dimethyl sulfate footprinting reveals the effect of pseudouridine in aminoglycoside binding to helix 69. ...
structure of the Cas9–sgRNA complex, we identify regions of sgRNA that can be modified while maintaining or enhancing genome-editing activity, and we develop an optimal set of chemical modifications forin vivoapplications. Using lipid nanoparticle formulations of these enhanced sgRNAs (e-sgRNA) and...
A Chemical Method for Site-Specific Modification of RNA: The Convertible Nucleoside Approach Knowledge of RNA structure can greatly facilitate the understanding of its biological function. However, the physical properties of RNA, especially its con... CR Allerson,SL Chen,GL Verdine - 《Journal of...
MicroRNA silencing for cancer therapy targeted to the tumour microenvironment We find that the attachment of peptide nucleic acid antimiRs to a peptide with a low pH-induced transmembrane structure (pHLIP) produces a novel ... CJ Cheng,R Bahal,IA Babar,... - 《Nature》 被引量: 414发表: ...
Ch 9. The Nucleotide Structure of DNA & RNA DNA: Chemical Structure of Nucleic Acids & Phosphodiester Bonds 6:36 8:08 Next Lesson Adenine, Thymine, Guanine & Cytosine | Overview & Pairing Complementary Base Pairing | Definition, Rules & Examples 8:18 DNA: Discovery, Facts, Structure ...