Stromal-Immune Cell Interactions in Health and Disease Timothy S. Zheng Jay S. Fine Jonathon D. Sedgwick Sponsor Feature18 Feb 2021 Further reading Cross-tissue organization of the fibroblast lineage Single-cell and genetic tools are used to characterize the diversity of fibroblasts across health...
This chapter describes the current knowledge on cellular interactions during the bone repair as well as cytokines and growth factors mediating these processes. The roles of emerging innate immune cell populations, innate lymphoid cells are also discussed. Based on this current knowledge, we conclude ...
Our ambition is to bring the next generation of breakthrough therapies to patients, and we see the area of stroma cell-immune cell interactions as the next frontier of innovation. By sponsoring this collection, we wish to call attention to this emerging biology and its vast potential to govern...
Immune suppression is a hallmark of the TME, and fibroblast–macrophage interactions facilitate this process (Fig.2a). Zhang et al. revealed that CAFs interacted with monocytes via the IL-8/CCR2 pathway, thereby inducing M2-type macrophages, which protected cancer cells from NK cell-mediated kill...
Therefore, DSC cells are involved in modulating the immune system both through cell-to-cell contact and through soluble factors and paracrine effects like MSCs [13]. Compared to other mesenchymal stromal cells, DSCs have higher expression of programmed death-ligand 1 (PD-L 1) and PD-L2, thus...
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks 2021, Trends in Immunology Citation Excerpt : In the omentum, fat-associated lymphoid clusters (FALCs), known as milky spots, appear as dispersed immune cell aggregates underpinned by CCL19...
In multiple myeloma (MM), bone marrow mesenchymal stromal cells (BM-MSCs) play an important role in pathogenesis and disease progression by supporting myeloma cell growth and immune escape. Previous studies have suggested that direct and indirect interactions between malignant cells and BM-MSCs result...
Further studies showed that MSCs also had immunosuppressive activity on both the adaptive and natural immune system, thereby endorsing them as the perfect cell source for tissue repair. The Special Feature contains review articles covering topics that largely focus on the interactions of MSCs ...
Orchestration of bone repair processes requires crosstalk between different cell populations, including immune cells and mesenchymal stem/stromal cells (MSC). Extracellular vesicles (EV) as mediators of these interactions remain vastly unexplored. Here, we aimed to determine the mechanism of MSC recruitmen...
Stromal–immune cell interactions Nature Immunology (Nat Immunol)ISSN1529-2916(online)ISSN1529-2908(print) Sign up for theNature Briefingnewsletter — what matters in science, free to your inbox daily. Email address Sign up I agree my information will be processed in accordance with theNatureand ...