After pretreatment with TUDCA, Cd reduced the level of ERS to a certain extent; however, at these doses, there were no significant changes in the expression of Nrf2. Conclusion Cadmium can result in ERS and oxidative stress in the kidneys of rats, activate Nrf2, and upregulate the ...
Here we show in a pre-clinical model, designed to investigate the comorbid effects of psychological stress on microbial composition and immune pathways in the gut, that stress induces a multidimensional loss of host protection, provoking a dysbiotic shift in the ileal microbiome dominated by AIEC an...
Microglial function declines during aging. The interaction of microglia with the gut microbiota has been well characterized during development and adulthood but not in aging. Here, we compared microglial transcriptomes from young-adult and aged mice housed under germ-free and specific pathogen-free cond...
Functional interactions between the gut microbiota and host metabolism The link between the microbes in the human gut and V Tremaroli,F Backhed - 《Nature》 被引量: 2218发表: 2012年 Mechanisms of vascular aging: new perspectives. This review focuses on molecular, cellular, and functional changes...
In the UK, changes to the higher education system have increased the range of stressors experienced by students above those traditionally associated with the transition to university. Despite this, there is little qualitative research examining how students experience and cope with the adjustment to un...
B3. Climate-vegetation-soil Interactions and Long-term Hydrologic partitioning: Signatures of Catchment Co-evolution? Catchment hydrologic partitioning, regional vegetation composition and soil properties are strongly affected by climate (Budyko, 1974; Whittaker, 1962; Jenny, 1941), but the effects of ...
Dynamic rheology of sphere- and rod-based magnetorheological fluids The effect of particle shape in the small amplitude oscillatory shear behavior of magnetorheological (MR) fluids is investigated from zero magnetic field s... de Vicente, J.,Segovia-Gutie?rrez, J. P.,E Andablo-Reyes,... - ...
Gut microbiota and its metabolites (short-chain fatty acids, SCFA) have attracted extensive attention for their usefulness in regulating immune system development and function, strengthening the gut barrier, metabolizing undigested nutrients and xenobiotics, mitigating oxidative stress, and eliminating pathoge...
The thyroid, the eyes and the gut: a possible connection INTRODUCTION: Graves' disease (GD) is an autoimmune disorder responsible for 60-90% of thyrotoxicosis, with an incidence of 1 to 2 cases per 1000 populatio... D Covelli,M Ludgate - 《Journal of Endocrinological Investigation》 被引量...
Alcohol use disorders are associated with altered stress responses, but the impact of stress or stress hormones on alcohol-associated tissue injury remain unknown. We evaluated the effects of chronic restraint stress on alcohol-induced gut barrier dysfunction and liver damage in mice. To determine whe...