first-line treatment for advanced NSCLC in CheckMate 227 part 1: efficacy by KRAS, TP53, STK11, and KEAP1 mutation status. Presented at: 2021 ESMO Immuno-Oncology Congress; December 9, 2021; virtual. Presentation 40. [8].Di Federico A...
lung cancerpembrolizumabCancers harboring serine threonine kinase (STK11) alteration or SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1 (SMARCB1) mutation are conventionally considered as treatment-refractory to immune checkpoint inhibitors or chemotherapy, ...
此外,对STK11缺失和SMARCB1缺陷突变的认知有助于加强对有效的治疗方案的开发,并扩大我们对罕见基因突变的潜在机制和病理意义的理解。 参考文献:Chen J, Wang J. STK11 loss and SMARCB1 deficiency mutation in a dedifferentiated lung cancer patient present response to neo-adjuvant treatment with pembrolizumab and...
参考文献: Chen J, Wang J. STK11 loss and SMARCB1 deficiency mutation in a dedifferentiated lung cancer patient present response to neo-adjuvant treatment with pembrolizumab and platinum doublet: A case report. Front Onc...
Clinical data have shown that Serine/Threonine Kinase 11 (STK11) mutation may be associated with an immunosuppressive tumor microenvironment (ITEM) and poor prognosis and failure of anti-PD-1 (αPD1) treatment in non-small cell lung cancer (NSCLC). To explore the potential of restoring STK11 ...
Xu et al. BMC Cancer (2024) 24:491 https://doi.org/10.1186/s12885-024-12130-y BMC Cancer RESEARCH Open Access Effect of the STK11 mutation on therapeutic efficacy and prognosis in patients with non- small cell lung cancer: a comprehensive study based on meta-analyses and bioinformatics ...
EGFR and ALK testing has become essential in the treatment of patients with advanced non–small-cell lung cancer, present in up to 50% of Asian lung adenocarcinomas populations in contrast to only 5% to 15% in a non-Asian population.13, 14, 15, 16 This underscores the need to search ...
STK11/KEAP1 Co-mutation Predicts Short Overall Survival in Patients with LUAD, Independent of KRAS Status MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actional Cancer Targets) is a clinically deployed next-generation sequencing panel that detects mutations, select translocations,...
参考文献:Chen J, Wang J. STK11 loss and SMARCB1 deficiency mutation in a dedifferentiated lung cancer patient present response to neo-adjuvant treatment with pembrolizumab and platinum doublet: A case report. Front Oncol. 2023 Jan 27;13:1088534. doi: 10.3389/fonc.2023.1088534. PMID: 36776287; ...
This article reviews the research progress of the correlation between STK11 gene mutation and immunotherapy on NSCLC.夏思雨赵梓彤李里Cancer Research on Prevention & Treatment