Xu et al. BMC Cancer (2024) 24:491 https://doi.org/10.1186/s12885-024-12130-y BMC Cancer RESEARCH Open Access Effect of the STK11 mutation on therapeutic efficacy and prognosis in patients with non- small cell
Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer XIA Siyu, ZHAO Zitong, LI Li, Medical Oncology Second Ward, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China More Information 摘要 摘要 HTML全文 图(1) 表(0) 参考文献...
[5] Zhao N, Wilkerson MD, Shah U, et al. Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma[J]. Lung ...
Background: STK11 mutation in non-small cell lung cancer (NSCLC) is associated with worse survival as well as primary resistance to PD-1/PD-L1 targeting immunotherapy. We hypothesize that co-occurring mutations and tumor mutation burden (TMB) may impact response to therapy and prognosis. ...
STK11 is a tumor suppressor gene, which affects cellular processes such as cellular metabolism, cell polarization, regulation of apoptosis, and DNA damage response [4]. Somatic loss-of‐function mutation of STK11 occurs in multiple cancer types, especially in lung adenocarcinomas [5], and can le...
STK11/KEAP1 Co-mutation Predicts Short Overall Survival in Patients with LUAD, Independent of KRAS Status MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actional Cancer Targets) is a clinically deployed next-generation sequencing panel that detects mutations, select translocations,...
12 In cytologically proven adrenal metastasis from patients with treatment naive lung adenocarcinoma, we aimed to identify the prevalence of STK11 mutant status and concomitant STK11/KRAS mutant status with a targeted next-generation sequencing-based approach using a 50-gene cancer hotspot panel. ...
A search of the literature was made using the electronic database MEDLINE (National Library of Medicine, USA) for additional mutations reported to be associated with PJS which were not referenced in the Human Gene Mutation Database. LKB1/STK11 protein sequences of Homo sapiens (GenBank accession...
Liver kinase 1 (LKB1 also known as STK11) is a tumor suppressor gene that is inactivated by bi-allelic mutation in non-small cell lung cancer (NSCLC), malignant melanoma and cervical cancer. LKB1 protein has a central kinase domain, two N-terminal nuclear leading sequences, and a C-termin...
Non-small cell lung cancerLKB1/STK11Advanced stageMutationsKRASPrognostic biomarkerHighlights " LKB1/STK11 (STK11) is an onco-suppressor gene frequently inactivated in NSCLC. " STK11 mutations were evaluated in a cohort largely enriched for advanced stages. " STK11 and KRAS status were ...