Johnson, B.E.; Kwiatkowski,D.J.; et al. Characteristics and Outcomes of Patients With Metastatic KRAS-Mutant Lung Adenocarcinomas: The Lung Cancer Mutation Consortium Experience. J. Thorac. Oncol. Off. Publ. Int. Assoc. Study Lung Cancer ...
This study was conducted to investigate the relationship between STK11 genetic alterations and the outcomes of patients with metastatic EGFR mutant lung cancer. Clinical characteristics and genomic data were downloaded from the cBioPortal database. The information of the case with STK11 mutation was ...
此外,对STK11缺失和SMARCB1缺陷突变的认知有助于加强对有效的治疗方案的开发,并扩大我们对罕见基因突变的潜在机制和病理意义的理解。 参考文献:Chen J, Wang J. STK11 loss and SMARCB1 deficiency mutation in a dedifferentiated lung cancer patient present response to neo-adjuvant treatment with pembrolizumab and...
参考文献: Chen J, Wang J. STK11 loss and SMARCB1 deficiency mutation in a dedifferentiated lung cancer patient present response to neo-adjuvant treatment with pembrolizumab and platinum doublet: A case report. Front Onc...
Additionally, tumors harboring the LKB1Y49D mutation showed phenotypic features compatible with the molecular profile induced by this isoform. Fig. 6: Distinct contributions of LKB1 mutant isoforms to in vivo tumor growth. a In vivo tumor growth upon expression of LKB1WT (n = 5 per group)...
Correlation Between STK11 Gene Mutation and Immunotherapy of Non-small Cell Lung Cancer XIA Siyu, ZHAO Zitong, LI Li, Medical Oncology Second Ward, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China More Information 摘要 摘要 HTML全文 图(1) 表(0) 参考文献...
STK11/KEAP1 Co-mutation Predicts Short Overall Survival in Patients with LUAD, Independent of KRAS Status MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actional Cancer Targets) is a clinically deployed next-generation sequencing panel that detects mutations, select translocations,...
ＳＴＫ１１与ＫＲＡＳ共突变的晚期肺腺癌患者的诊治经过。该患者经一线至四线方案的积极治疗，疾病始 终呈现持续进展（一线使用Ａ Ｃ化疗联合帕博利珠单抗治疗，二线白蛋白紫杉醇联合贝伐珠单抗及帕博利珠单抗治疗，三线ＧＰ化疗联合帕博利珠单抗治疗，四线采用安罗替尼联合帕博利珠单抗治疗）。对于驱动基因突变阴性且Ｐ ...
Routine EGFR and KRAS mutation analysis using COLD-PCR in non-small cell lung cancer Int J Clin Pract, 66 (2012), pp. 748-752 CrossrefView in ScopusGoogle Scholar 16 HS Shim, H Lee da, EJ Park, SH Kim Histopathologic characteristics of lung adenocarcinomas with epidermal growth factor rece...
1、Cancer Genome Atlas Research N. Comprehensive molecular profiling of lung adenocarcinoma. 2、The prevalence and prognostic significance of KRAS mutation subtypes in lung adenocarcinomas from Chinese populations. 3、Co-occurring genomic alterations define major subsets of KRAS - mutant lung adenocarcinoma...