[6] Borun P, De Rosa M, Nedoszytko B, Walkowiak J, Plawski A. Specific Alu elements involved in a significant percentage of copy number variations of the STK11 gene in patients with Peutz-Jeghers syndrome. Fam Cancer. 2015 Sep;14(3):455-61. doi: 10.1007/s10689-015-9800-5. PMID: ...
Mutations analysis of STK11 gene in Chinese families with Peutz-Jeghers syndrome[J]. KANG Lianchun1*, ZHAO Xirong1*, ZHOU Yongshuang1, JIA Yixing1, KANG Suhai1, CHEN Zhu1, ZHAO Min2, CUI Jiantao2, LI Wenmei2, SUN Anle1 & LU Youyong2 1. The 264 Hospital of People Liberation ...
2019, 22(4): 233-238. [Chen J, Jiang D, Huang F. Advances of the Correlation between Driver Gene Status and Immunotherapy in Non-small Cell Lung Cancer[J]. Zhongguo Fei Ai Za Zhi, 2019, 22(4): 233-238.]
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal ...
【 Key words 】STK11 gene; Cervical cancer; Gene expression 宫颈癌是继乳腺癌后最常见的妇科恶性肿瘤,死亡率位居妇女恶性肿瘤首位。高危型人乳头瘤病毒(human papilloma virus,HPV)是导致宫颈癌的关键致病因子,其发病原因与发生过程被多种因子综合影响。研究显示,基因启动子甲基化的研究,在恶性肿瘤生物学领域研究...
Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] [中文简述(自动翻译):] 该基因,其编码的丝氨酸/苏氨酸激酶家族的一个成员,调节细胞极性和用作肿瘤抑制基因。在这种基因突变与黑斑息肉综合征,常染色体显性遗传...
Mutations in STK11gene in Czech Peutz-Jeghers patients. Vasovcák P,PuchmajerováA,Roubalík J,KrepelováA. BMC Medical Genetics . 2009Vasovcak P, Puchmajerova A, Roubalik J, Krepelova A. Mutations in STK11 gene in Czech Peutz-Jeghers patients. BMC Med Genet 2009; 10: 69...
Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.包装清单: 产品编号 产品名称 包装 L16581 STK11 Knockout Lentivirus 108 TU — 说明书 1份 保存条件:-80℃保存,至少一年有效。
Objective To detect mutations of STK11 gene in peripheral blood and hamartomatous gastrointestinal polypi of 2 pedigrees and 3 sporadic patients with PJS. Methods Blood samples were obtained from some members in the 2 pedigrees, 3 sporadic patients, and 100 normal human controls, and tissue sample...
Gene+OncoD 组织基因检测 检测结果 手术组织检测发现5个体细胞突变,其中包括STK11失活突变以及KRAS激活突变。 结果解读 STK11基因负调控mTOR信号通路,该基因失活突变使mTOR信号通路持续激活,因此对mTOR抑制剂可能敏感。mTOR抑制剂获批用于肾癌,乳腺癌的治疗,mTOR抑制剂通常需要和其它治疗方案联合治疗。肺癌中KRAS激活突变...