Most cases of PJS involve the inactivation of germline mutations in the serine/threonine kinase gene STK11 which is also known as LKB1. The function of STK11 was previously linked to the tumor suppressor p53 and was shown to activate the p53 target p21/ WAF1. Recently, STK11 was reported ...
Entrez Gene ID:(Human) 114790 功能 protein kinase bindingchaperonescaffold/adaptor protein 参与通路 protein localization Cookie设置 我们及我们的关联方等通过运用Cookie等技术来为您提供您感兴趣的网站定制内容、识别访问者、保障安全登录和收集数据。点击“全部接受”以接受所有 cookie 并直接跳转至网站,或点击“管...
Currently, only mutations in the gene STK11 (also known as LKB1; OMIM 602216) at chromosome 19p13.3 have been identified as a cause of PJS [4, 5]. The human STK11 gene encodes a 433 amino acid serine-threonine kinase. STK11 is known to be located both in the nucleus and the cytopla...
1, Mee Song1, Sang-Min Jeon4, Woo-Young Kim5, Gordon B. Mills6,Yong-Yeon Cho3 & Sukjoon Yoon1,2 Although STK11 (LKB1) mutation is a major mediator of lung cancer progression, targeted therapy has not been implemented due to STK11 mutations being loss-of-function. ...
(Thr172)expression was significantly lower in gastric,colonic,and uterine polyps from PJS patients with missense variations than in non-PJS patients.Our findings indicate that these two missense STK11 variants are likely pathogenic and inactivate the STK11 gene,causing it to lose its function of ...
Ng, P. C. & Henikoff, S. Predicting the Effects of Amino Acid Substitutions on Protein Function.Annu. Rev. Genomics Hum. Genet.7, 61–80 (2006). ArticleCASPubMedGoogle Scholar Wang, Z.et al. A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Chinese patients....
May regulate STK11/LKB1 function by controlling its subcellular localization. 仅用于科研。不用于诊断过程。未经明确授权不得转售。 相关产品 蛋白质免疫印迹 Secondary Antibodies WB内参抗体 蛋白电泳 WB转印膜组 WB底物 Labeling Kits WB Catalog # A32816 ...
MA 05.02 STK11/LKB1 Loss of Function Genomic Alterations Predict Primary Resistance to PD-1/PD-L1 Axis Blockade in KRAS-Mutant NSCLC KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) co-mutations define distinct...
Given our clinical data supporting STK11/KEAP1 cooperativity, regardless of KRAS status, we investigated whether loss-of-function mutations in both STK11 and KEAP1 promote cell proliferation more than either single gene loss in a KRAS-independent manner. We used CRISPR/Cas9 gene editing to create...
Characterization of the STK11 splicing variant as a normal splicing isomer in a patient with Peutz-Jeghers syndrome harboring genomic deletion of the STK11 gene [J]. Hum Genome Var, 2016, 3:16002. [8] Shorning BY, Clarke AR. Energy sensing and cancer: LKB1 function and lessons learnt ...