G did not change, confirming that hypoglycemia was not the stimulus for GLN secretion. Intravenous SRIF (50 μg bolus followed by 200 μg per hr) begun in the fetus 10 min. before delivery did not affect low fetal GLN. Despite ongoing SRIF, CCT was followed 15 min. later by a surge...
Characterization of the Glucagon Response to Hypoglycemia in Man Thus, in man, hypoglycemia is a potent stimulus for glucagon secretion. The rate of fall of plasma glucose as well as the degree and duration of hypoglycemia are important determinants of the glucagon response. These findings suggest ...
Thus, humoral agents such as parathyroid hormone, glucagon, methylxanthines, adenosine compounds, and calcium ionophores that have profound effects on membrane potential and calcium movements in cells might be expected to regulate renin secretion in an ordered and predictable fashion. 展开 ...
In addition to increased secretion of cortisol by the adrenal cortex, activation of the fight-or-flight response causes increased secretion of glucagon by the islet cells of the pancreas and increased secretion of catecholamines (i.e., epinephrine and norepinephrine) by the adrenal medulla. The tis...
Which type of stimulus causes glucagon secretion? a. Neural stimulus b. Hormonal stimulus c. Humoral stimulusMatch each endocrine gland with a hormone the gland releases and one of the functions of that hormone. Endocrine gland Hormone released Function of hormone Posterior pituitary...
Venous blood samples were taken for counterregulatory hormones (adrenaline, noradrenaline [norepinephrine], glucagon and lactate) at baseline of both the rest and HIT intervention visits with samples also taken after the third and fourth bouts of exercise during the HIT intervention. Each participant...
The interplay between cyclic AMP and ions in the stimulus-secretion coupling in pancreatic B-cells In 1965, Samols et al. reported that administration of glucagon to man increases plasma insulin levels before any change in plasma glucose levels. This obs... JC Henquin - 《Archives Internationale...
The use of the glucagon-like peptide 1 receptor agonists is increasing and that of sulfonylurea is decreasing. A better understanding of the stimulus-secretion coupling may lead to the discovery of other molecular targets for development of drugs for the prevention and treatment of type 2 diabetes...
Hyperaminoacidemia is a powerful stimulus of pancreatic glucagon secretion. These studies were designed to elucidate the role of aminogenic hyperglucagonemia in glucoregulation. Conscious dogs with previously implanted indwelling venous ... RH Unger,A Ohneda,E Aguilar-Parada,... - 《Journal of Clin...
We propose that the interaction of cAMP and Epac to trigger CICR explains, at least in part, the blood glucose-lowering properties of an insulinotropic hormone (glucagon-like peptide-1, also known as GLP-1) now under investigation for use in the treatment of type-2 diabetes mellitus....