Stepped-Wedge Trial Design: A PrimerMona KanaanDavid J TorgersonAda KedingNoreen MdegeJessica KaszaKarla Hemming
Stepped-wedge trial is an emerging cluster randomized controlled trial in the field of service provision and policy evaluation, which is becoming increasingly popular among health care researchers in recent years. There is no need to set up a special control group for stepped-wedge trials, and the...
[2] Li, S., et al., Rational and design of astepped-wedgeclusterrandomized trial evaluating quality improvement initiativefor reducing cardiovascular events among patients with acute coronary syndromesin resource-constrained hospitals in China. Am Heart J...
In a longitudinal or cohort trial, subjects are followed over time.Section "Introduction" introduces cluster randomized trials and stepped wedge trials and gives some definitions. Section "Design of Cluster Randomized Trials" is concerned with the design of cluster randomized trials and how to ...
We then go on to describe how the design of such trials can be optimized to balance between minimizing the cost of the trial, and minimizing some function of the covariance matrix of the treatment effect estimates. Using a recently commenced trial that will evaluate the effectiveness of sensor ...
A stepped wedge trial based on randomising the time at which individuals, rather than clusters, receive the intervention is possible, but uncommon in the literature [3]. Two systematic reviews have been published on stepped wedge randomised controlled trials (SWTs). The first was conducted by ...
(Brown & Lilford, 2006) ⇒Celia A Brown, andRichard J Lilford. (2006). “The Stepped Wedge Trial Design: A Systematic Review.” BioMed Central Ltd.doi:10.1186/1471-2288-6-54 Subject Headings:Stepped Wedge Trial Notes Cited By
A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered. This paper reports on the experiences and lessons learned from the conduct of a cluster randomized, stepped we...
This makes the stepped wedge design particularly useful for evaluating the population-level impact of an intervention that has been shown to be effective in an individually randomized trial. The unidirectional aspect of the crossover does, however, complicate the analysis since the treatment effect ...
A cross-over trial A multiple baseline study Advantages Solves ethical dilemma of withholding the intervention when not in equipoise Solves logistical and financial problems associated with simultaneous implementation Can detect trends Increases statistical power (within and between comparisons) Can study th...