The importance of randomisation in a stepped wedge trial is that the effects of time can be estimated from the data, and bias from secular trends that would otherwise arise can be controlled for, provided the trends are correctly specified in the model....
Stepped wedge trial designs should be reported more clearly. Researchers should consider the use of stratified and/or restricted randomisation. Trials should generally not commit resources to collect outcome data from individuals exposed a long time before or after the rollout period. Though substantial...
[2] Li, S., et al., Rational and design of astepped-wedgeclusterrandomized trial evaluating quality improvement initiativefor reducing cardiovascular events among patients with acute coronary syndromesin resource-constrained hospitals in China. Am Heart J...
We then go on to describe how the design of such trials can be optimized to balance between minimizing the cost of the trial, and minimizing some function of the covariance matrix of the treatment effect estimates. Using a recently commenced trial that will evaluate the effectiveness of sensor ...
I1 Introduction Mona Kanaan, Noreen Dadirai Mdege, Ada Keding O1 The HiSTORIC trial: a hybrid before-and-after and stepped wedge design RA Parker, N Mills, A Shah, F Strachan, C Keerie, CJ Weir O2 Stepped wedge trials with non-uniform correlation structu
This makes the stepped wedge design particularly useful for evaluating the population-level impact of an intervention that has been shown to be effective in an individually randomized trial. The unidirectional aspect of the crossover does, however, complicate the analysis since the treatment effect ...
Stepped-wedge trial is an emerging cluster randomized controlled trial in the field of service provision and policy evaluation, which is becoming increasingly popular among health care researchers in recent years. There is no need to set up a special control group for stepped-wedge trials, and the...
(e.g., policy changes at a hospital) or for practical or logistical reasons. To date, most CRTs have mirrored the design of individually randomized trials and used a parallel or matched parallel two group design. One exception is the stepped wedge trial (SWT) design. The SWT is a more ...
We sought to optimise the design of stepped wedge trials with an equal allocation of clusters to sequences and explored sample size comparisons with alternative trial designs. We developed a new expression for the design effect for a stepped wedge trial, assuming that observations are equally correl...
(Brown & Lilford, 2006) ⇒Celia A Brown, andRichard J Lilford. (2006). “The Stepped Wedge Trial Design: A Systematic Review.” BioMed Central Ltd.doi:10.1186/1471-2288-6-54 Subject Headings:Stepped Wedge Trial Notes Cited By