Stepped-Wedge Trial Design: A PrimerMona KanaanDavid J TorgersonAda KedingNoreen MdegeJessica KaszaKarla Hemming
We then go on to describe how the design of such trials can be optimized to balance between minimizing the cost of the trial, and minimizing some function of the covariance matrix of the treatment effect estimates. Using a recently commenced trial that will evaluate the effectiveness of sensor ...
[2] Li, S., et al., Rational and design of astepped-wedgeclusterrandomized trial evaluating quality improvement initiativefor reducing cardiovascular events among patients with acute coronary syndromesin resource-constrained hospitals in China. Am Heart J...
Stepped-wedge trial is an emerging cluster randomized controlled trial in the field of service provision and policy evaluation, which is becoming increasingly popular among health care researchers in recent years. There is no need to set up a special control group for stepped-wedge trials, and the...
Actual cluster sizes could be compared with those assumed during the sample size calculation for 14 (26%) of the trial reports; the cluster sizes were between 29% and 480% of that which had been assumed. Cluster sizes often vary in SW-CRTs. Reporting of SW-CRTs also remains suboptimal. ...
The stepped-wedge (SW) cluster randomized controlled trial, in which clusters cross over in a randomized sequence from control to intervention, is ideal for the implementation and testing of complex health service interventions. In certain cases however, implementation of the intervention may pose logi...
(Brown & Lilford, 2006) ⇒Celia A Brown, andRichard J Lilford. (2006). “The Stepped Wedge Trial Design: A Systematic Review.” BioMed Central Ltd.doi:10.1186/1471-2288-6-54 Subject Headings:Stepped Wedge Trial Notes Cited By
Stepped wedge trial designs should be reported more clearly. Researchers should consider the use of stratified and/or restricted randomisation. Trials should generally not commit resources to collect outcome data from individuals exposed a long time before or after the rollout period. Though substantial...
This trial aimed to improve nutritional status during radiation therapy (RT) using a novel method of training dietitians to deliver psychological techniques to improve nutritional behaviors in patients with HNC. Methods and Materials This trial used a stepped-wedge, randomized controlled design to ...
The Surgery As Needed for Oesophageal cancer (SANO) trial is an ongoing phase-III trial that compares active surveillance with standard oesophagectomy for patients with a clinically complete response (cCR; i.e. no evidence of residual disease on diagnostics) to neoadjuvant chemoradiotherapy for oesoph...